A symphony on C: orchestrating DNA repair for gene expression via cytosine modification The 2012 IMB Conference: DNA Demethylation, Repair and Beyond Institute of Molecular Biology, Mainz, Germany, 18-21 October 2012

Marianne G. Rots; Svend K. Petersen-Mahrt

doi:10.2217/EPI.12.73

A symphony on C: orchestrating DNA repair for gene expression via cytosine modification The 2012 IMB Conference: DNA Demethylation, Repair and Beyond Institute of Molecular Biology, Mainz, Germany, 18-21 October 2012

Marianne G. Rots^*, Svend K. Petersen-Mahrt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

Headline-grabbing attention has been given to DNA demethylation pathways as new epigenetic mechanisms, with reviews and hypotheses outnumbering research papers. As candidate proteins for DNA demethylation include well-known DNA repair enzymes, it was timely to join epigenetics and DNA repair experts at the first international meeting on DNA Demethylation, Repair and Beyond. New mechanistic insights were presented for known players orchestrating the symphony on cytosine - 'the symphony on C' (TET1, 2, 3; GADD45; AID; and TDG), while new instruments and classical themes were pulled into the amalgamation. What may appear as just an unintentional cacophony of random oxidative lesions and abasic sites in a bed of chromatin noise may turn out to be a gene-expressing regulatory melody.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Epigenomics
Volume	5
Issue number	1
DOIs	https://doi.org/10.2217/EPI.12.73
Publication status	Published - Feb-2013

Keywords

5-METHYLCYTOSINE
5-HYDROXYMETHYLCYTOSINE
METHYLATION
ACTIVATION
PATHWAY
CELLS

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title = "A symphony on C: orchestrating DNA repair for gene expression via cytosine modification The 2012 IMB Conference: DNA Demethylation, Repair and Beyond Institute of Molecular Biology, Mainz, Germany, 18-21 October 2012",

abstract = "Headline-grabbing attention has been given to DNA demethylation pathways as new epigenetic mechanisms, with reviews and hypotheses outnumbering research papers. As candidate proteins for DNA demethylation include well-known DNA repair enzymes, it was timely to join epigenetics and DNA repair experts at the first international meeting on DNA Demethylation, Repair and Beyond. New mechanistic insights were presented for known players orchestrating the symphony on cytosine - 'the symphony on C' (TET1, 2, 3; GADD45; AID; and TDG), while new instruments and classical themes were pulled into the amalgamation. What may appear as just an unintentional cacophony of random oxidative lesions and abasic sites in a bed of chromatin noise may turn out to be a gene-expressing regulatory melody.",

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A symphony on C: orchestrating DNA repair for gene expression via cytosine modification The 2012 IMB Conference: DNA Demethylation, Repair and Beyond Institute of Molecular Biology, Mainz, Germany, 18-21 October 2012. / Rots, Marianne G.; Petersen-Mahrt, Svend K.
In: Epigenomics, Vol. 5, No. 1, 02.2013, p. 25-28.

Research output: Contribution to journal › Article › Academic › peer-review

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