A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

Saleh Hamieh; R. Frederick Ludlow; Olivier Perraud; Kevin R. West; Elio Mattia; Sijbren Otto

doi:10.1021/ol302260n

A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

Saleh Hamieh, R. Frederick Ludlow, Olivier Perraud, Kevin R. West, Elio Mattia, Sijbren Otto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.

Original language	English
Pages (from-to)	5404-5407
Number of pages	4
Journal	Organic letters
Volume	14
Issue number	21
DOIs	https://doi.org/10.1021/ol302260n
Publication status	Published - 2-Nov-2012

Keywords

CATION-PI INTERACTION
CHEMISTRY
BINDING
RECOGNITION

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title = "A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library",

abstract = "Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.",

keywords = "CATION-PI INTERACTION, CHEMISTRY, BINDING, RECOGNITION",

author = "Saleh Hamieh and Ludlow, {R. Frederick} and Olivier Perraud and West, {Kevin R.} and Elio Mattia and Sijbren Otto",

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AU - Perraud, Olivier

AU - West, Kevin R.

AU - Mattia, Elio

AU - Otto, Sijbren

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AB - Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.

KW - CATION-PI INTERACTION

KW - CHEMISTRY

KW - BINDING

KW - RECOGNITION

U2 - 10.1021/ol302260n

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A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

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Keywords

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