A systematic literature review: prescribing indicators related to type 2 diabetes mellitus and cardiovascular risk management

Liana Martirosyan, Jaco Voorham, Flora M. Haaijer-Ruskamp, Joze Braspenning, Bruce H. R. Wolffenbuttel, Petra Denig

Research output: Contribution to journalReview articleAcademicpeer-review

16 Citations (Scopus)

Abstract

Purpose Valid prescribing indicators (PI) are needed for reliable assessment of prescribing quality. The purpose of this study is to describe the validity of existing PI for type 2 diabetes mellitus and cardiovascular risk management.

Methods We conducted a systematic literature search for studies describing the development and assessment of relevant Pis between January 1990 and January 2009. We grouped identified PI as drug- or disease-oriented, and according to the aspects of prescribing addressed and the additional clinical information included. We reviewed the clinimetric characteristics of the different types of PI.

Results We identified 59 documents describing the clinimetrics of 16 types of PI covering relevant prescribing aspects, including first-choice treatment, safety issues, dosing, costs, sufficient and timely treatment. We identified three types of drug-oriented, and five types of disease-oriented PI with proven face and content validity as well as operational feasibility in different settings. PI focusing on treatment modifications were the only indicators that showed concurrent validity. Several solutions were proposed for dealing with ease-mix and sample size problems, but their actual effect on PI scores was insufficiently assessed. Predictive validity of individual PI is not yet known.

Conclusion We identified a range of existing PI that are valid for internal quality assessment as they are evidence-based, accepted by professionals, and reliable. For external use, problems of patient case-mix and sample size per PI should be better addressed. Further research is needed for selecting indicators that predict clinical outcomes. Copyright (C) 2009 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)319-334
Number of pages16
JournalPharmacoepidemiology and Drug Safety
Volume19
Issue number4
DOIs
Publication statusPublished - Apr-2010

Keywords

  • quality of care assessment
  • prescribing quality indicator
  • clinimetric properties
  • type 2 diabetes mellitus
  • cardiovascular risk management
  • QUALITY-OF-CARE
  • INAPPROPRIATE MEDICATION USE
  • VULNERABLE OLDER PATIENTS
  • GENERAL-PRACTITIONERS
  • PERFORMANCE INDICATORS
  • ADMINISTRATIVE DATA
  • EXPLICIT CRITERIA
  • AMBULATORY-CARE
  • HEALTH-CARE
  • HYPERTENSION

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