A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

S. B. Jensen*, A. M. L. Pedersen, A. Vissink, E. Andersen, C. G. Brown, A. N. Davies, J. Dutilh, J. S. Fulton, L. Jankovic, N. N. F. Lopes, A. L. S. Mello, L. V. Muniz, C. A. Murdoch-Kinch, R. G. Nair, J. J. Napenas, A. Nogueira-Rodrigues, D. Saunders, B. Stirling, I. von Bueltzingsloewen, D. S. WeikelF. K. L. Spijkervet, M. T. Brennan, MASCC ISOO, L. Elting

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

205 Citations (Scopus)

Abstract

This systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations.

The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. For each article, two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results, and conclusions.

Seventy-two interventional studies met the inclusion criteria. In addition, 49 intensity-modulated radiation therapy (IMRT) studies were included as a management strategy aiming for less salivary gland damage. Management guideline recommendations were drawn up for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer.

There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment. Management guideline recommendations are provided for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Fields of sparse literature identified included effects of gustatory and masticatory stimulation, specific oral mucosal lubricant formulas, submandibular gland transfer, acupuncture, hyperbaric oxygen treatment, management strategies in pediatric cancer populations, and the economic consequences of salivary gland hypofunction and xerostomia.

Original languageEnglish
Pages (from-to)1061-1079
Number of pages22
JournalSupportive Care in Cancer
Volume18
Issue number8
DOIs
Publication statusPublished - Aug-2010

Keywords

  • Cancer therapy
  • Radiotherapy
  • Chemotherapy
  • Salivary gland hypofunction
  • Xerostomia
  • Quality of life
  • INTENSITY-MODULATED RADIOTHERAPY
  • PAROTID-SPARING RADIOTHERAPY
  • SQUAMOUS-CELL CARCINOMA
  • BONE-MARROW-TRANSPLANTATION
  • RADIATION-INDUCED XEROSTOMIA
  • LOCALLY ADVANCED HEAD
  • 5-YEAR FOLLOW-UP
  • ACCELERATED HYPERFRACTIONATED RADIOTHERAPY
  • QUANTITATIVE PERTECHNETATE SCINTIGRAPHY
  • LOCOREGIONALLY ADVANCED-CARCINOMA

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