A Trifunctional, Modular Biomaterial Coating: Nonadhesive to Bacteria, Chlorhexidine-Releasing and Tissue-Integrating

Jelmer Sjollema*, Heidrun Keul, Henny van der Mei, Rene Dijkstra, Minie Rustema-Abbing, Joop de Vries, Ton Loontjens, Ton Dirks, Henk Busscher

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Various potential anti-infection strategies can be thought of for biomaterial implants and devices. Permanent, tissue-integrated implants such as artificial joint prostheses require a different anti-infection strategy than, for instance, removable urinary catheters. The different requirements set to biomaterials implants and devices in different clinical applications call for tailor-made strategies. Here, a modular coating-concept for biomaterials is reported, which in its full, trifunctional form comprises nonadhesiveness to bacteria and antimicrobial release, combined with enhanced tissue integration characteristics. Nonadhesiveness to proteins and bacteria is accomplished by a hydrophilic brush coating (Vitrostealth). The antimicrobial release module is constituted by a chlorhexidine releasing poly(ethylene glycol) diacrylamide based-coating that continues to release its antimicrobial content also when underneath the nonadhesive top-coating. The third module, enhancing tissue integration, is realized by the incorporation of the penta-peptide Glycine-Arginine-Glycine-Aspartic acid-Serine (GRGDS) within the nonadhesive top-coating. Modules function in concert or independently of each other. Specifically, tissue integration by the GRGDS-module does not affect the nonadhesiveness of the Vitrostealth-module toward bovine serum albumin and Staphylococcus aureus, while the antimicrobial release module does not affect tissue-integration by the GRGDS-module. Uniquely, using this modular system, tailor-made anti-infection strategies can thus readily be made for biomaterials in different clinical applications.

Original languageEnglish
Article number1600336
Number of pages10
JournalMacromolecular Bioscience
Volume17
Issue number4
DOIs
Publication statusPublished - Apr-2017

Keywords

  • antimicrobial
  • biomaterial
  • coating
  • infection
  • polymer brush
  • release
  • tissue integration
  • PROTEIN ADSORPTION
  • CELL-ADHESION
  • IN-VITRO
  • SURFACES
  • ANTIBIOTICS
  • INFECTIONS
  • IMPLANTS
  • ANTISEPTICS
  • STRATEGIES
  • INTEGRINS

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