A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide

Adriaan J Minnaard*, Ruben Andringa, Niels de Kok, Arnold Driessen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established 13 C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.

Original languageEnglish
JournalAngewandte Chemie (International ed. in English)
DOIs
Publication statusE-pub ahead of print - 30-Apr-2021

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