A Unified Approach for the Total Synthesis of cyclo-Archaeol, iso-Caldarchaeol, Caldarchaeol, and Mycoketide

Ruben L. H. Andringa, Niels A. W. de Kok, Arnold J. M. Driessen, Adriaan J. Minnaard*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
67 Downloads (Pure)


Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established 13C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.

Original languageEnglish
Pages (from-to) 17497-17503
Number of pages7
JournalAngewandte Chemie (International ed. in English)
Issue number32
Early online date30-Apr-2021
Publication statusPublished - 2-Aug-2021


  • Archaea
  • asymmetric hydrogenation
  • lipids
  • membrane spanning
  • metathesis

Cite this