Abstract
Ir-catalyzed asymmetric alkene hydrogenation is presented as the strategy par excellence to prepare saturated isoprenoids and mycoketides. This highly stereoselective synthesis approach is combined with an established 13C-NMR method to determine the enantioselectivity of each methyl-branched stereocenter. It is shown that this analysis is fit for purpose and the combination allows the synthesis of the title compounds with a significant increase in efficiency.
Original language | English |
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Pages (from-to) | 17497-17503 |
Number of pages | 7 |
Journal | Angewandte Chemie (International ed. in English) |
Volume | 60 |
Issue number | 32 |
Early online date | 30-Apr-2021 |
DOIs | |
Publication status | Published - 2-Aug-2021 |
Keywords
- Archaea
- asymmetric hydrogenation
- lipids
- membrane spanning
- metathesis