Abdominal aortic calcification detected by dual X-ray absorptiometry: A strong predictor for cardiovascular events

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Abstract

Background. Vertebral fracture assessment (VFA) using dual-energy X-ray absorptiometry can visualize abdominal aortic calcification (AAC). AAC correlates with total atherosclerosis burden. We questioned whether VFA-detected AAC could be used for cardiovascular risk assessment.

Methods. VFA images of 2,500 subjects were evaluated to detect and score AAC (n = 164). A random age- and gender-matched set of subjects (n = 325) without AAC served as control group. Patients with prior cardiovascular disease or procedures were excluded. Base-line cardiovascular risk factors and further cardiovascular events were checked. Design-based Cox regression analysis was used to examine the prognostic value of AAC for cardiovascular outcomes.

Results. AAC-positive subjects were divided into two groups: low-AAC (score 1-3), and high-AAC group (score > 3). Mean age in the groups was 68, 68, and 71 years, percentage of females was 64.4%, 61%, and 66.1%, and the proportion of cardiovascular events within groups was 1.5%, 6.7%, and 11.9% in control, low-AAC, and high-AAC groups, respectively. Age- and gender-adjusted as well as multivariable analysis showed a significant, higher risk for cardiovascular events incidence in AAC-positive, low-AAC, and high-AAC when compared to the control group.

Interpretation. AAC assessed with routine VFA was shown to be a strong predictor for cardiovascular events.

Original languageEnglish
Pages (from-to)539-545
Number of pages7
JournalAnnals of medicine
Volume42
Issue number7
DOIs
Publication statusPublished - Oct-2010

Keywords

  • AAC
  • abdominal aortic calcification
  • cardiovascular event
  • DEXA
  • VFA
  • INCIDENT MYOCARDIAL-INFARCTION
  • RISK-FACTORS
  • POSTMENOPAUSAL WOMEN
  • COMPUTED-TOMOGRAPHY
  • DISEASE
  • ATHEROSCLEROSIS
  • ANTHROPOMETRY
  • ROTTERDAM
  • DEPOSITS
  • FAT

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