Abnormalities in myocardial contractility, metabolism and perfusion reserve in non-stenotic coronary segments in heart failure patients

AFM van den Heuvel*, JJ Bax, PK Blanksma, W Vaalburg, HJGM Crijns, DJ van Veldhuisen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Abstract

Objective: Myocardial blood flow (MBF) reserve is impaired in congestive heart failure (CHF), while fluorine-18-deoxyglucose ((18)FDG) uptake is relatively preserved. To determine whether this mismatch could be interpreted as ischemia, we performed dobutamine stress echocardiography (DSE). Methods: 12 males with coronary artery disease (CAD) and CHF were compared with 12 controls with similar CAD but normal left ventricular (LV) function. MBF in non-infarct-related artery areas was assessed using [N-13]ammonia positron emission tomography (PET), at rest and after dipyridamole infusion and (18)FDG uptake was determined. DSE was performed with doses up to 40 mug/kg per min. Results: In areas with non-stenotic arteries MBF reserve was more impaired in CHF patients (1.6+/-1-0.6 vs. 2.2+/-0.5; CHF versus normal LV, respectively, P

Original languageEnglish
Article numberPII S0008-6363(02)00331-0
Pages (from-to)97-103
Number of pages7
JournalCardiovascular Research
Volume55
Issue number1
Publication statusPublished - Jul-2002

Keywords

  • heart failure
  • ischemia
  • regional blood flow
  • cardiomyopathy
  • energy metabolism
  • DOBUTAMINE STRESS ECHOCARDIOGRAPHY
  • IDIOPATHIC DILATED CARDIOMYOPATHY
  • LEFT-VENTRICULAR DYSFUNCTION
  • BLOOD-FLOW RESERVE
  • HIBERNATING MYOCARDIUM
  • STUNNED MYOCARDIUM
  • ARTERY DISEASE
  • N-13 AMMONIA
  • CARDIAC PET
  • ISCHEMIA

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