Accelerating chemical reactions by molecular sledding

Lei Zhang, Lifei Zheng, Zhuojun Meng, Konstantin Balinin, Mark Loznik, Andreas Herrmann

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

The speed-up of covalent bond formation was achieved between a sulfhydryl group and a 2-bromopropionic acid derivative by utilizing sliding peptide-modified substrates. Moreover, a new type of DNA cleaving reagent was developed, consisting of pVIc covalently coupled to verteporfin. This peptide-porphyrin conjugate allowed targeting of DNA and resulted in increased photodegradation of double-stranded nucleic acids.

Original languageEnglish
Pages (from-to)6331-6334
Number of pages4
JournalChemical Communications
Volume53
Issue number47
DOIs
Publication statusPublished - 14-Jun-2017

Keywords

  • VERTEPORFIN PHOTODYNAMIC THERAPY
  • VIRAL-PROTEINASE
  • DNA
  • PEPTIDE
  • CELLS
  • DIFFUSION

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