Accumulation of Advanced Glycation End Products and Chronic Complications in ESRD Treated by Dialysis

Robbert Meerwaldt*, Clark J. Zeebregts, Gerjan Navis, Jan-Luuk Hillebrands, Joop D. Lefrandt, Andries J. Smit

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

Cardiovascular and connective tissue disorders are very common in patients with end-stage renal disease (ESRD), and the accumulation of advanced glycation end products (AGEs) is significantly increased in these patients. Accumulation of AGEs is believed to have a role in tissue protein aging and the pathogenesis of such age-related diseases as diabetes and ESRD. AGEs accumulate in patients with ESRD as a result of nonenzymatic glycation, oxidative stress, and diminished clearance of AGE precursors. Some AGEs show characteristic brown pigmentation and fluorescence, form protein-protein cross-links, and may ligate with AGE-specific receptors, inducing oxidative stress and cytokine production. This review focuses on the clinical relevance of AGE accumulation in patients with ESRD treated by dialysis for the development of long-term complications. The formation and accumulation of AGEs in patients with ESRD are discussed, as well as the relationship between AGE accumulation and such major complications of ESRD as cardiovascular and connective tissue disorders. Am J Kidney Dis 53:138-150. (C) 2008 by the National Kidney Foundation, Inc.

Original languageEnglish
Pages (from-to)138-150
Number of pages13
JournalAmerican Journal of Kidney Diseases
Volume53
Issue number1
DOIs
Publication statusPublished - Jan-2009

Keywords

  • Advanced glycation end products
  • uremia
  • end-stage renal disease
  • cardiovascular disease
  • connective tissue
  • transplantation
  • STAGE RENAL-DISEASE
  • ADVANCED GLYCOSYLATION ENDPRODUCTS
  • KIDNEY-PANCREAS TRANSPLANTATION
  • GLUCOSE DEGRADATION PRODUCTS
  • STREPTOZOTOCIN-DIABETIC RAT
  • CARDIOVASCULAR RISK-FACTORS
  • AGE-INHIBITOR PYRIDOXAMINE
  • TERM HEMODIALYSIS-PATIENTS
  • OXIDATIVE STRESS
  • PERITONEAL-DIALYSIS

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