Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease

JWL Hartog, APJ De Vries, HL Lutgers, R Meerwaldt, RM Huisman, WJ Van Son, PE De Jong, AJ Smit*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

83 Citations (Scopus)

Abstract

Advanced glycation end products (AGEs) accumulate during renal failure and dialysis. Kidney transplantation is thought to reverse this accumulation by restoring renal function. Using a noninvasive and validated autofluorescence reader, we evaluated AGE levels in 285 transplant recipients (mean age, 52 years; range, 41 to 60 years), 32 dialysis patients (mean age, 56 years; range, 43 to 65 years), and 231 normal control subjects (mean age, 51 years; range, 40 to 65 years). Measurements in transplant recipients were performed for a mean of 73 months (range, 32 to 143 months) after transplantation. Dialysis patients were on dialysis therapy for a mean of 42 months (range, 17 to 107 months). Fluorescence was significantly increased in dialysis patients compared with normal control subjects (2.8 vs. 2.0 arbitrary units [a.u.], P

Original languageEnglish
Title of host publicationMAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE
EditorsJW Baynes, VM Monnier, JM Ames, Thorpe
Place of PublicationNEW YORK
PublisherNew York Academy of Sciences
Pages299-307
Number of pages9
ISBN (Print)1-57331-531-1
DOIs
Publication statusPublished - 2005
Event8th International Symposium on the Maillard Reaction - , Seychelles
Duration: 29-Aug-20041-Sept-2004

Publication series

NameANNALS OF THE NEW YORK ACADEMY OF SCIENCES
PublisherNEW YORK ACAD SCIENCES
Volume1043
ISSN (Print)0077-8923

Other

Other8th International Symposium on the Maillard Reaction
Country/TerritorySeychelles
Period29/08/200401/09/2004

Keywords

  • kidney transplantation
  • dialysis
  • advanced glycation end products
  • renal disease
  • OXIDATIVE STRESS
  • DIABETES-MELLITUS
  • FAILURE
  • PENTOSIDINE
  • AGE
  • COMPLICATIONS
  • FLUORESCENCE
  • DYSFUNCTION
  • CATABOLISM
  • COLLAGEN

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