Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease

JWL Hartog; APJ De Vries; HL Lutgers; R Meerwaldt; RM Huisman; WJ Van Son; PE De Jong; AJ Smit

doi:10.1196/annals.1333.037

Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease

JWL Hartog, APJ De Vries, HL Lutgers, R Meerwaldt, RM Huisman, WJ Van Son, PE De Jong, AJ Smit^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

85 Citations (Scopus)

Abstract

Advanced glycation end products (AGEs) accumulate during renal failure and dialysis. Kidney transplantation is thought to reverse this accumulation by restoring renal function. Using a noninvasive and validated autofluorescence reader, we evaluated AGE levels in 285 transplant recipients (mean age, 52 years; range, 41 to 60 years), 32 dialysis patients (mean age, 56 years; range, 43 to 65 years), and 231 normal control subjects (mean age, 51 years; range, 40 to 65 years). Measurements in transplant recipients were performed for a mean of 73 months (range, 32 to 143 months) after transplantation. Dialysis patients were on dialysis therapy for a mean of 42 months (range, 17 to 107 months). Fluorescence was significantly increased in dialysis patients compared with normal control subjects (2.8 vs. 2.0 arbitrary units [a.u.], P

Original language	English
Title of host publication	MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE
Editors	JW Baynes, VM Monnier, JM Ames, Thorpe
Place of Publication	NEW YORK
Publisher	New York Academy of Sciences
Pages	299-307
Number of pages	9
ISBN (Print)	1-57331-531-1
DOIs	https://doi.org/10.1196/annals.1333.037
Publication status	Published - 2005
Event	8th International Symposium on the Maillard Reaction - , Seychelles Duration: 29-Aug-2004 → 1-Sept-2004

Publication series

Name	ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Publisher	NEW YORK ACAD SCIENCES
Volume	1043
ISSN (Print)	0077-8923

Other

Other	8th International Symposium on the Maillard Reaction
Country/Territory	Seychelles
Period	29/08/2004 → 01/09/2004

Keywords

kidney transplantation
dialysis
advanced glycation end products
renal disease
OXIDATIVE STRESS
DIABETES-MELLITUS
FAILURE
PENTOSIDINE
AGE
COMPLICATIONS
FLUORESCENCE
DYSFUNCTION
CATABOLISM
COLLAGEN

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Hartog, JWL., De Vries, APJ., Lutgers, HL., Meerwaldt, R., Huisman, RM., Van Son, WJ., De Jong, PE., & Smit, AJ. (2005). Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease. In JW. Baynes, VM. Monnier, JM. Ames, & Thorpe (Eds.), MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE (pp. 299-307). (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; Vol. 1043). New York Academy of Sciences. https://doi.org/10.1196/annals.1333.037

Hartog, JWL ; De Vries, APJ ; Lutgers, HL et al. / Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease. MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE. editor / JW Baynes ; VM Monnier ; JM Ames ; Thorpe. NEW YORK : New York Academy of Sciences, 2005. pp. 299-307 (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES).

@inproceedings{72155e76877643eb8ef5afed19486403,

title = "Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease",

abstract = "Advanced glycation end products (AGEs) accumulate during renal failure and dialysis. Kidney transplantation is thought to reverse this accumulation by restoring renal function. Using a noninvasive and validated autofluorescence reader, we evaluated AGE levels in 285 transplant recipients (mean age, 52 years; range, 41 to 60 years), 32 dialysis patients (mean age, 56 years; range, 43 to 65 years), and 231 normal control subjects (mean age, 51 years; range, 40 to 65 years). Measurements in transplant recipients were performed for a mean of 73 months (range, 32 to 143 months) after transplantation. Dialysis patients were on dialysis therapy for a mean of 42 months (range, 17 to 107 months). Fluorescence was significantly increased in dialysis patients compared with normal control subjects (2.8 vs. 2.0 arbitrary units [a.u.], P",

keywords = "kidney transplantation, dialysis, advanced glycation end products, renal disease, OXIDATIVE STRESS, DIABETES-MELLITUS, FAILURE, PENTOSIDINE, AGE, COMPLICATIONS, FLUORESCENCE, DYSFUNCTION, CATABOLISM, COLLAGEN",

author = "JWL Hartog and {De Vries}, APJ and HL Lutgers and R Meerwaldt and RM Huisman and {Van Son}, WJ and {De Jong}, PE and AJ Smit",

year = "2005",

doi = "10.1196/annals.1333.037",

language = "English",

isbn = "1-57331-531-1",

series = "ANNALS OF THE NEW YORK ACADEMY OF SCIENCES",

publisher = "New York Academy of Sciences",

pages = "299--307",

editor = "JW Baynes and VM Monnier and JM Ames and Thorpe",

booktitle = "MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE",

note = "8th International Symposium on the Maillard Reaction ; Conference date: 29-08-2004 Through 01-09-2004",

}

Hartog, JWL, De Vries, APJ, Lutgers, HL, Meerwaldt, R, Huisman, RM, Van Son, WJ, De Jong, PE & Smit, AJ 2005, Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease. in JW Baynes, VM Monnier, JM Ames & Thorpe (eds), MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1043, New York Academy of Sciences, NEW YORK, pp. 299-307, 8th International Symposium on the Maillard Reaction, Seychelles, 29/08/2004. https://doi.org/10.1196/annals.1333.037

Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease. / Hartog, JWL; De Vries, APJ; Lutgers, HL et al.
MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE. ed. / JW Baynes; VM Monnier; JM Ames; Thorpe. NEW YORK: New York Academy of Sciences, 2005. p. 299-307 (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; Vol. 1043).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease

AU - Hartog, JWL

AU - De Vries, APJ

AU - Lutgers, HL

AU - Meerwaldt, R

AU - Huisman, RM

AU - Van Son, WJ

AU - De Jong, PE

AU - Smit, AJ

PY - 2005

Y1 - 2005

N2 - Advanced glycation end products (AGEs) accumulate during renal failure and dialysis. Kidney transplantation is thought to reverse this accumulation by restoring renal function. Using a noninvasive and validated autofluorescence reader, we evaluated AGE levels in 285 transplant recipients (mean age, 52 years; range, 41 to 60 years), 32 dialysis patients (mean age, 56 years; range, 43 to 65 years), and 231 normal control subjects (mean age, 51 years; range, 40 to 65 years). Measurements in transplant recipients were performed for a mean of 73 months (range, 32 to 143 months) after transplantation. Dialysis patients were on dialysis therapy for a mean of 42 months (range, 17 to 107 months). Fluorescence was significantly increased in dialysis patients compared with normal control subjects (2.8 vs. 2.0 arbitrary units [a.u.], P

AB - Advanced glycation end products (AGEs) accumulate during renal failure and dialysis. Kidney transplantation is thought to reverse this accumulation by restoring renal function. Using a noninvasive and validated autofluorescence reader, we evaluated AGE levels in 285 transplant recipients (mean age, 52 years; range, 41 to 60 years), 32 dialysis patients (mean age, 56 years; range, 43 to 65 years), and 231 normal control subjects (mean age, 51 years; range, 40 to 65 years). Measurements in transplant recipients were performed for a mean of 73 months (range, 32 to 143 months) after transplantation. Dialysis patients were on dialysis therapy for a mean of 42 months (range, 17 to 107 months). Fluorescence was significantly increased in dialysis patients compared with normal control subjects (2.8 vs. 2.0 arbitrary units [a.u.], P

KW - kidney transplantation

KW - dialysis

KW - advanced glycation end products

KW - renal disease

KW - OXIDATIVE STRESS

KW - DIABETES-MELLITUS

KW - FAILURE

KW - PENTOSIDINE

KW - AGE

KW - COMPLICATIONS

KW - FLUORESCENCE

KW - DYSFUNCTION

KW - CATABOLISM

KW - COLLAGEN

U2 - 10.1196/annals.1333.037

DO - 10.1196/annals.1333.037

M3 - Conference contribution

SN - 1-57331-531-1

T3 - ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

SP - 299

EP - 307

BT - MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE

A2 - Baynes, JW

A2 - Monnier, VM

A2 - Ames, JM

A2 - Thorpe, null

PB - New York Academy of Sciences

CY - NEW YORK

T2 - 8th International Symposium on the Maillard Reaction

Y2 - 29 August 2004 through 1 September 2004

ER -

Hartog JWL, De Vries APJ, Lutgers HL, Meerwaldt R, Huisman RM, Van Son WJ et al. Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease. In Baynes JW, Monnier VM, Ames JM, Thorpe, editors, MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE. NEW YORK: New York Academy of Sciences. 2005. p. 299-307. (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES). doi: 10.1196/annals.1333.037

Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease

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