ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity

Fedaa Ali, Menattallah Elserafy, Mohamed H. Alkordi*, Muhamed Amin*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
17 Downloads (Pure)

Abstract

The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.

Original languageEnglish
Article number100798
Number of pages4
JournalBiochemistry and Biophysics Reports
Volume24
Early online date20-Aug-2020
DOIs
Publication statusPublished - Dec-2020

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