Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids

Robert Hoen; J. A. F. Boogers; Heiko Bernsmann; A. J. Minnaard; A. Meetsma; Theodora Tiemersma-Wegman; A. H. M. de Vries; J. G. de Vries; B. L. Feringa

doi:10.1002/anie.200500784

Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids

Robert Hoen, J. A. F. Boogers, Heiko Bernsmann, A. J. Minnaard, A. Meetsma, Theodora Tiemersma-Wegman, A. H. M. de Vries, J. G. de Vries, B. L. Feringa

Research output: Contribution to journal › Article › Academic › peer-review

168 Citations (Scopus)

Original language	English
Pages (from-to)	4209-4212
Number of pages	4
Journal	Angewandte Chemie-International Edition
Volume	44
Issue number	27
DOIs	https://doi.org/10.1002/anie.200500784
Publication status	Published - 4-Jul-2005

Keywords

asymmetric catalysis
hydrogenation
ligand effects
phosphines
rhodium
MONODENTATE P-LIGANDS
TRANSITION-METAL CATALYSIS
GAMMA-SECRETASE INHIBITORS
CHIRAL BUILDING-BLOCK
ASYMMETRIC HYDROGENATION
COMBINATORIAL APPROACH
PHOSPHORAMIDITE LIGANDS
MIXTURES
POTENT
PRINCIPLE

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CCDC 263274: Experimental Crystal Structure Determination
Hoen, R. (Contributor), Boogers, J. A. F. (Contributor), Bernsmann, H. (Contributor), Minnaard, A. (Contributor), Meetsma, A. (Contributor), Tiemersma-Wegman, T. (Contributor), De Vries, A. H. M. (Contributor), De Vries, J. G. (Contributor) & Feringa, B. L. (Contributor), University of Groningen, 10-Feb-2005
DOI: 10.5517/cc8tyqq
Dataset
CCDC 263275: Experimental Crystal Structure Determination
Hoen, R. (Contributor), Boogers, J. A. F. (Contributor), Bernsmann, H. (Contributor), Minnaard, A. (Contributor), Meetsma, A. (Contributor), Tiemersma-Wegman, T. (Contributor), De Vries, A. H. M. (Contributor), De Vries, J. G. (Contributor) & Feringa, B. L. (Contributor), University of Groningen, 10-Feb-2005
DOI: 10.5517/cc8tyrr
Dataset

Cite this

Hoen, R., Boogers, J. A. F., Bernsmann, H., Minnaard, A. J., Meetsma, A., Tiemersma-Wegman, T., de Vries, A. H. M., de Vries, J. G., & Feringa, B. L. (2005). Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids. Angewandte Chemie-International Edition, 44(27), 4209-4212. https://doi.org/10.1002/anie.200500784

@article{421f693a64ca425682fa776816961466,

title = "Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,{\ss}-disubstituted unsaturated acids",

keywords = "asymmetric catalysis, hydrogenation, ligand effects, phosphines, rhodium, MONODENTATE P-LIGANDS, TRANSITION-METAL CATALYSIS, GAMMA-SECRETASE INHIBITORS, CHIRAL BUILDING-BLOCK, ASYMMETRIC HYDROGENATION, COMBINATORIAL APPROACH, PHOSPHORAMIDITE LIGANDS, MIXTURES, POTENT, PRINCIPLE",

author = "Robert Hoen and Boogers, {J. A. F.} and Heiko Bernsmann and Minnaard, {A. J.} and A. Meetsma and Theodora Tiemersma-Wegman and {de Vries}, {A. H. M.} and {de Vries}, {J. G.} and Feringa, {B. L.}",

note = "Cited By (since 1996): 64",

year = "2005",

month = jul,

day = "4",

doi = "10.1002/anie.200500784",

language = "English",

volume = "44",

pages = "4209--4212",

journal = "Angewandte Chemie-International Edition",

issn = "1433-7851",

publisher = "WILEY-V C H VERLAG GMBH",

number = "27",

}

Hoen, R, Boogers, JAF, Bernsmann, H, Minnaard, AJ, Meetsma, A, Tiemersma-Wegman, T, de Vries, AHM, de Vries, JG & Feringa, BL 2005, 'Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids', Angewandte Chemie-International Edition, vol. 44, no. 27, pp. 4209-4212. https://doi.org/10.1002/anie.200500784

Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids. / Hoen, Robert; Boogers, J. A. F.; Bernsmann, Heiko et al.
In: Angewandte Chemie-International Edition, Vol. 44, No. 27, 04.07.2005, p. 4209-4212.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids

AU - Hoen, Robert

AU - Boogers, J. A. F.

AU - Bernsmann, Heiko

AU - Minnaard, A. J.

AU - Meetsma, A.

AU - Tiemersma-Wegman, Theodora

AU - de Vries, A. H. M.

AU - de Vries, J. G.

AU - Feringa, B. L.

N1 - Cited By (since 1996): 64

PY - 2005/7/4

Y1 - 2005/7/4

KW - asymmetric catalysis

KW - hydrogenation

KW - ligand effects

KW - phosphines

KW - rhodium

KW - MONODENTATE P-LIGANDS

KW - TRANSITION-METAL CATALYSIS

KW - GAMMA-SECRETASE INHIBITORS

KW - CHIRAL BUILDING-BLOCK

KW - ASYMMETRIC HYDROGENATION

KW - COMBINATORIAL APPROACH

KW - PHOSPHORAMIDITE LIGANDS

KW - MIXTURES

KW - POTENT

KW - PRINCIPLE

U2 - 10.1002/anie.200500784

DO - 10.1002/anie.200500784

M3 - Article

SN - 1433-7851

VL - 44

SP - 4209

EP - 4212

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

IS - 27

ER -

Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids

Keywords

Access to Document

Handle.net

Embargoed Document

Datasets

CCDC 263274: Experimental Crystal Structure Determination

CCDC 263275: Experimental Crystal Structure Determination

Cite this