Achiral ligands dramatically enhance rate and enantioselectivity in the Rh/phosphoramidite-catalyzed hydrogenation of a,ß-disubstituted unsaturated acids

Robert Hoen, J. A. F. Boogers, Heiko Bernsmann, A. J. Minnaard, A. Meetsma, Theodora Tiemersma-Wegman, A. H. M. de Vries, J. G. de Vries, B. L. Feringa

Research output: Contribution to journalArticleAcademicpeer-review

166 Citations (Scopus)
Original languageEnglish
Pages (from-to)4209-4212
Number of pages4
JournalAngewandte Chemie-International Edition
Volume44
Issue number27
DOIs
Publication statusPublished - 4-Jul-2005

Keywords

  • asymmetric catalysis
  • hydrogenation
  • ligand effects
  • phosphines
  • rhodium
  • MONODENTATE P-LIGANDS
  • TRANSITION-METAL CATALYSIS
  • GAMMA-SECRETASE INHIBITORS
  • CHIRAL BUILDING-BLOCK
  • ASYMMETRIC HYDROGENATION
  • COMBINATORIAL APPROACH
  • PHOSPHORAMIDITE LIGANDS
  • MIXTURES
  • POTENT
  • PRINCIPLE

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