Acquired bleeding disorders

Andreas Tiede*, Barbara Zieger, Ton Lisman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Acquired bleeding disorders can accompany hematological, neoplastic, autoimmune, cardiovascular or liver diseases, but can sometimes also arise spontaneously. They can manifest as single factor deficiencies or as complex hemostatic abnormalities. This review addresses (a) acquired hemophilia A, an autoimmune disorder characterized by inhibitory autoantibodies against coagulation factor VIII; (b) acquired von Willebrand syndrome in patients with cardiovascular disorders, where shear stress abnormalities result in destruction of von Willebrand factor; and (c) liver function disorders that comprise complex changes in pro- and anti-hemostatic factors, whose clinical implications are often difficult to predict. The article provides an overview on the pathophysiology, diagnostic tests and state-of-the-art treatment strategies.

Original languageEnglish
Number of pages9
JournalHaemophilia
DOIs
Publication statusE-pub ahead of print - 1-Jun-2020

Keywords

  • Coagulation Protein Disorders
  • Hemophilia A
  • Liver disease
  • Von Willebrand Disease
  • VON-WILLEBRAND-FACTOR
  • HEMOPHILIA-A
  • FACTOR-VIII
  • VENOUS THROMBOEMBOLISM
  • INVASIVE PROCEDURES
  • PORCINE SEQUENCE
  • LIVER-DISEASE
  • MANAGEMENT
  • CIRRHOSIS
  • ANTICOAGULATION

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