ACRODERMATITIS CHRONICA ATROPHICANS - A LIGHT AND ELECTRON-MICROSCOPIC STUDY

J DEKONING; DJ TAZELAAR; JAA HOOGKAMPKORSTANJE; JD ELEMA

ACRODERMATITIS CHRONICA ATROPHICANS - A LIGHT AND ELECTRON-MICROSCOPIC STUDY

J DEKONING^*, DJ TAZELAAR, JAA HOOGKAMPKORSTANJE, JD ELEMA

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

Degeneration of the elastica and collagen fibres in skin biopsies from patients with acrodermatitis chronica atrophicans was studied with light and electron microscopy. Elastic fibres were involved in the infiltrative stage while the elastin plexus was still present. In the atrophic phase, only fragments of elastic and oxytalan fibres were seen and the elaunin plexus was absent. Some collagen fibres were surrounded by osmiophilic material. In all biopsies, myelin sheaths were collapsed without axon structures. Spirochetes could be demonstrated in 69% of the biopsies and were most numerous in infiltrative and nodular lesions. The loss of elasticity of the skin in the atrophic phase may be caused by the destruction of both elastic and elastin fibres.

Original language	English
Pages (from-to)	23-32
Number of pages	10
Journal	Journal of Cutaneous Pathology
Volume	22
Issue number	1
Publication status	Published - Feb-1995

Keywords

LYME-DISEASE
BORRELIA-BURGDORFERI
MIGRANS AFZELIUS
ELASTIC FIBERS
SKIN-LESIONS
SPIROCHETOSIS
DIAGNOSIS

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title = "ACRODERMATITIS CHRONICA ATROPHICANS - A LIGHT AND ELECTRON-MICROSCOPIC STUDY",

abstract = "Degeneration of the elastica and collagen fibres in skin biopsies from patients with acrodermatitis chronica atrophicans was studied with light and electron microscopy. Elastic fibres were involved in the infiltrative stage while the elastin plexus was still present. In the atrophic phase, only fragments of elastic and oxytalan fibres were seen and the elaunin plexus was absent. Some collagen fibres were surrounded by osmiophilic material. In all biopsies, myelin sheaths were collapsed without axon structures. Spirochetes could be demonstrated in 69% of the biopsies and were most numerous in infiltrative and nodular lesions. The loss of elasticity of the skin in the atrophic phase may be caused by the destruction of both elastic and elastin fibres.",

keywords = "LYME-DISEASE, BORRELIA-BURGDORFERI, MIGRANS AFZELIUS, ELASTIC FIBERS, SKIN-LESIONS, SPIROCHETOSIS, DIAGNOSIS",

author = "J DEKONING and DJ TAZELAAR and JAA HOOGKAMPKORSTANJE and JD ELEMA",

year = "1995",

month = feb,

language = "English",

volume = "22",

pages = "23--32",

journal = "Journal of Cutaneous Pathology",

issn = "0303-6987",

publisher = "Wiley",

number = "1",

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TY - JOUR

T1 - ACRODERMATITIS CHRONICA ATROPHICANS - A LIGHT AND ELECTRON-MICROSCOPIC STUDY

AU - DEKONING, J

AU - TAZELAAR, DJ

AU - HOOGKAMPKORSTANJE, JAA

AU - ELEMA, JD

PY - 1995/2

Y1 - 1995/2

N2 - Degeneration of the elastica and collagen fibres in skin biopsies from patients with acrodermatitis chronica atrophicans was studied with light and electron microscopy. Elastic fibres were involved in the infiltrative stage while the elastin plexus was still present. In the atrophic phase, only fragments of elastic and oxytalan fibres were seen and the elaunin plexus was absent. Some collagen fibres were surrounded by osmiophilic material. In all biopsies, myelin sheaths were collapsed without axon structures. Spirochetes could be demonstrated in 69% of the biopsies and were most numerous in infiltrative and nodular lesions. The loss of elasticity of the skin in the atrophic phase may be caused by the destruction of both elastic and elastin fibres.

AB - Degeneration of the elastica and collagen fibres in skin biopsies from patients with acrodermatitis chronica atrophicans was studied with light and electron microscopy. Elastic fibres were involved in the infiltrative stage while the elastin plexus was still present. In the atrophic phase, only fragments of elastic and oxytalan fibres were seen and the elaunin plexus was absent. Some collagen fibres were surrounded by osmiophilic material. In all biopsies, myelin sheaths were collapsed without axon structures. Spirochetes could be demonstrated in 69% of the biopsies and were most numerous in infiltrative and nodular lesions. The loss of elasticity of the skin in the atrophic phase may be caused by the destruction of both elastic and elastin fibres.

KW - LYME-DISEASE

KW - BORRELIA-BURGDORFERI

KW - MIGRANS AFZELIUS

KW - ELASTIC FIBERS

KW - SKIN-LESIONS

KW - SPIROCHETOSIS

KW - DIAGNOSIS

M3 - Article

SN - 0303-6987

VL - 22

SP - 23

EP - 32

JO - Journal of Cutaneous Pathology

JF - Journal of Cutaneous Pathology

IS - 1

ER -

ACRODERMATITIS CHRONICA ATROPHICANS - A LIGHT AND ELECTRON-MICROSCOPIC STUDY

Abstract

Keywords

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