Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

Mariël F van Stee; Albert A de Graaf; Albert K Groen

doi:10.1186/s12933-018-0738-4

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

Mariël F van Stee, Albert A de Graaf, Albert K Groen

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Abstract

Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.

Original language	English
Article number	94
Number of pages	22
Journal	Cardiovascular Diabetology
Volume	17
DOIs	https://doi.org/10.1186/s12933-018-0738-4
Publication status	Published - 30-Jun-2018

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10.1186/s12933-018-0738-4Licence: CC BY

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapyFinal publisher's version, 1.46 MBLicence: CC BY

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title = "Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy",

abstract = "Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.",

author = "{van Stee}, {Mari{\"e}l F} and {de Graaf}, {Albert A} and Groen, {Albert K}",

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AU - van Stee, Mariël F

AU - de Graaf, Albert A

AU - Groen, Albert K

PY - 2018/6/30

Y1 - 2018/6/30

N2 - Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.

AB - Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In this review, the proposed molecular mechanisms of action of statin and metformin therapy in patients with diabetes and dyslipidemia are critically assessed, and a hypothesis for mechanisms underlying interactions between these drugs in combination therapy is developed.

U2 - 10.1186/s12933-018-0738-4

DO - 10.1186/s12933-018-0738-4

M3 - Review article

C2 - 29960584

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VL - 17

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

M1 - 94

ER -

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

Abstract

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