Activation of serotonergic neurotransmission during the performance of aggressive behavior in rats

Bea J. van der Vegt, Natasja Lieuwes, Esther H.E.M. van de Wall, Katsunori Kato, Luis Moya-Albiol, Sonia Martínez-Sanchis, Sietse F. de Boer, Jaap M. Koolhaas

    Research output: Contribution to journalArticleAcademicpeer-review

    79 Citations (Scopus)

    Abstract

    High aggression is often linked to lowered serotonin (5-HT) neurotransmission. Although this may hold for high aggression as a trait characteristic of an individual, serotonergic activity is probably increased during performance of aggressive behavior. To test this hypothesis, first, the 5-HT1A agonist alnespirone and gamma aminobutyric acid-A agonist muscimol were administered into the dorsal raphe nucleus. These treatments, which inhibit 5-HT neuronal activity, were shown to decrease performance of aggressive behavior. Second, after a resident-intruder test, the activation of 5-HT neurons (measured by c-fos expression) was increased in high-aggressive rats, compared with low-aggressive rats or control rats that were not subjected to a social confrontation. Results show that performance of aggressive behavior increases 5-HT neuronal activity and that preventing this activation inhibits expression of aggressive behavior.

    Original languageEnglish
    Pages (from-to)667-674
    Number of pages8
    JournalBehavioral Neuroscience
    Volume117
    Issue number4
    DOIs
    Publication statusPublished - Aug-2003

    Keywords

    • Aggression
    • Animals
    • GABA Agonists
    • Male
    • Muscimol
    • Neurons
    • Rats
    • Serotonin
    • Serotonin Receptor Agonists
    • Spiro Compounds
    • Synaptic Transmission

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