Abstract

Cigarette smoking continues to be one of the major risk factors for increased morbidity and mortality worldwide. Among many adverse health effects, smoking can induce erythrocytosis, which is commonly believed to result from elevated serum erythropoietin (EPO) levels. Currently, however, this notion is only alleged, without data available to substantiate it. Hence, we analyzed data from the Prevention of Renal and Vascular End-Stage Disease study, a prospective population-based cohort study. Smoking behavior was quantified as number of cigarettes smoked per day and as 24-hour urinary cotinine excretion levels, an objective and quantitative measure of nicotine exposure. In 6808 community-dwelling participants, the prevalence of nonsmokers, former smokers, and current smokers were 29%, 43%, and 28%, respectively. Hematocrit levels were higher in current smokers (41.4% +/- 3.6%) than in nonsmokers (40.3% +/- 3.6%) (P

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalMayo clinic proceedings
Volume93
Issue number3
DOIs
Publication statusPublished - Mar-2018

Keywords

  • POLYCYTHEMIA-VERA
  • CIGARETTE-SMOKING
  • BLOOD HEMOGLOBIN
  • SMOKERS
  • SERUM
  • ALCOHOL
  • DISEASE
  • ERYTHROCYTOSIS
  • MUTATION
  • HEALTH

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