Acute effects of adaptive Deep Brain Stimulation in Parkinson's disease

Dan Piña Fuentes, J. Marc C. van Dijk, Jonathan Zijl, van, Harmen Moes, D L Marinus Oterdoom, Simon Little, Peter Brown, Martijn Beudel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background: Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson's disease (PD), when assessed in the immediate post-implantation phase. However, the potential benefits of aDBS in patients with electrodes chronically implanted, in whom changes due to the microlesion effect have disappeared, are yet to be assessed.

Methods: To determine the acute effectiveness and side-effect profile of aDBS in PD compared to conventional continuous DBS (cDBS) and no stimulation (NoStim), years after DBS implantation, 13 PD patients undergoing battery replacement were pseudo-randomised in a crossover fashion, into three conditions (NoStim, aDBS or cDBS), with a 2-min interval between them. Patient videos were blindly evaluated using a short version of the Unified Parkinson's Disease Rating Scale (subUPDRS), and the Speech Intelligibility Test (SIT).

Results: Mean disease duration was 16 years, and the mean time since DBS-implantation was 6.9 years. subUPDRS scores (11 patients tested) were significantly lower both in aDBS (p=

Conclusion: Beta-based aDBS is effective in PD patients with bradykinetic phenotypes, delivers less stimulation than cDBS, and potentially has a more favourable speech side-effect profile. Patients with prominent tremor may require a modified adaptive strategy. (C) 2020 Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)1507-1516
Number of pages10
JournalBrain stimulation
Issue number6
Early online date29-Jul-2020
Publication statusPublished - Nov-2020


  • Parkinson's disease
  • Adaptive deep brain stimulation
  • Subthalamic nucleus
  • Local field potentials
  • Beta oscillations
  • Closed-loop
  • Dysarthria

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