Acute intravenous versus chronic oral drug effects of verapamil on left ventricular diastolic function in patients with hypertrophic cardiomyopathy

JL POSMA*, PK BLANKSMA, E VAN DER WALL, KI LIE

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    The effects of acute intravenous (i.v.) versus long-term oral(p.o.) verapamil administration on diastolic function were studied in 20 patients with hypertrophic cardiomyopathy (HCM). We used a tip manometer catheter to record left ventricular pressure (LVP) tracings and a nuclear probe to measure LV volume changes. Infusion of verapamil resulted in an increase in time constant of relaxation (+15%, p <0.001); LV peak filling rate, heart rate (HR), and stiffness constant of the diastolic pressure-volume relation were unchanged. During 18-week p.o. verapamil treatment, HR decreased (-16%, p <0.0005) and the atrial contribution to LV filling decreased (-27%, p <0.05); other parameters differed significantly from baseline values. Results demonstrate that acute i.v. versus long-term p.o. verapamil administration have different effects on diastolic function in HCM.

    Original languageEnglish
    Pages (from-to)969-973
    Number of pages5
    JournalJournal of Cardiovascular Pharmacology
    Volume24
    Issue number6
    DOIs
    Publication statusPublished - Dec-1994

    Keywords

    • VERAPAMIL
    • HYPERTROPHY
    • CARDIOMYOPATHY
    • DIASTOLE
    • EXERCISE TOLERANCE
    • FILLING DYNAMICS
    • SHORT-TERM
    • RELAXATION
    • DISEASE
    • IMPROVEMENT
    • EXTENT
    • PROBE

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