Acute systemic complications in the preterm fetus after asphyxia: role of cardiovascular and blood flow responses

L Bennet*, L Booth, S C Malpas, J S Quaedackers, E Jensen, J Dean, A J Gunn

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

1. Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. There is very little information, and consequently considerable debate, about how or even whether to improve perfusion of the vital organs of this most vulnerable group of babies. Current treatments simply do not consistently improve babies' perfusion generally or kidney and gut perfusion and function in particular. 3. In this review we critically examine clinical and experimental evidence that suggests that exposure to low oxygen levels before and during birth may be a significant contributor to impaired systemic perfusion, and highlight areas requiring further research. 4. This knowledge is essential to develop and refine ways of improving perfusion of the kidneys and other vital organs in premature babies.

Original languageEnglish
Pages (from-to)291-9
Number of pages9
JournalClinical and Experimental Pharmacology and Physiology
Volume33
Issue number4
DOIs
Publication statusPublished - Apr-2006
Externally publishedYes

Keywords

  • Acute Disease
  • Asphyxia Neonatorum/complications
  • Cardiovascular Physiological Phenomena
  • Hemodynamics/physiology
  • Humans
  • Infant, Newborn
  • Infant, Premature/physiology
  • Regional Blood Flow/physiology

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