Additional work of breathing from trigger errors in mechanically ventilated children

Robert G T Blokpoel*, Alette A Koopman, Jefta van Dijk, Martin C J Kneyber

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
14 Downloads (Pure)

Abstract

BACKGROUND: Patient-ventilator asynchrony is associated with increased morbidity and mortality. A direct causative relationship between Patient-ventilator asynchrony and adverse clinical outcome have yet to be demonstrated. It is hypothesized that during trigger errors excessive pleural pressure swings are generated, contributing to increased work-of-breathing and self-inflicted lung injury. The objective of this study was to determine the additional work-of-breathing and pleural pressure swings caused by trigger errors in mechanically ventilated children.

METHODS: Prospective observational study in a tertiary paediatric intensive care unit in an university hospital. Patients ventilated > 24 h and < 18 years old were studied. Patients underwent a 5-min recording of the ventilator flow-time, pressure-time and oesophageal pressure-time scalar. Pressure-time-product calculations were made as a proxy for work-of-breathing. Oesophageal pressure swings, as a surrogate for pleural pressure swings, during trigger errors were determined.

RESULTS: Nine-hundred-and-fifty-nine trigger errors in 28 patients were identified. The additional work-of-breathing caused by trigger errors showed great variability among patients. The more asynchronous breaths were present the higher the work-of-breathing of these breaths. A higher spontaneous breath rate led to a lower amount of trigger errors. Patient-ventilator asynchrony was not associated with prolonged duration of mechanical ventilation or paediatric intensive care stay.

CONCLUSIONS: The additional work-of-breathing caused by trigger errors in ventilated children can take up to 30-40% of the total work-of-breathing. Trigger errors were less common in patients breathing spontaneously and those able to generate higher pressure-time-product and pressure swings.

TRIAL REGISTRATION: Not applicable.

Original languageEnglish
Article number296
Number of pages7
JournalRespiratory Research
Volume21
Issue number1
Early online date10-Nov-2020
DOIs
Publication statusPublished - 10-Nov-2020

Keywords

  • Mechanical ventilation
  • Ineffective triggering
  • Work-of-breathing
  • Patient&#8211
  • ventilator asynchrony
  • Paediatric
  • Patient self-inflicted-lung injury
  • TRANSPULMONARY PRESSURE
  • ASYNCHRONY
  • SUPPORT
  • IMPACT
  • ESOPHAGEAL

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