Adherence to Statin Therapy and Attainment of LDL Cholesterol Targets in an Outpatient Population of Type 2 Diabetes Patients: Analysis in the DIAbetes and LifEstyle Cohort Twente (DIALECT)

Jelle M. Beernink*, Milou M. Oosterwijk, Job F. M. van Boven, Hiddo J. L. Heerspink, Stephan J. L. Bakker, Gerjan Navis, Roos M. Nijboer, Christina M. Gant, Heleen Haverkate, Willemien J. Kruik-Kolloffel, Gozewijn D. Laverman

*Corresponding author for this work

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Objective: To assess adherence to statin therapy and its association with sociodemographic data, medical characteristics, LDLc levels, and LDLc target attainment in real-world T2D patients treated in secondary care.Research Design and Methods: Cross-sectional analyses were performed on baseline data of 393 patients in the DIAbetes and LifEstyle Cohort Twente (DIALECT). The medication possession ratio (MPR), calculated with pharmacy dispensing data, was used to determine adherence to statins for an intended period of 24 months. Statins were included in the analyses if they were used for at least six consecutive months with at least three dispenses. Adherence was defined as an MPR >= 80%. Associations with adherence were assessed using descriptive statistics and binary logistic regression.Results: Overall, 80% of the patients had a statin prescription and of those, 89% were adherent. The proportion of patients who reached LDLc targets of

Original languageEnglish
Article number888110
Number of pages9
JournalFrontiers in Pharmacology
Publication statusPublished - 12-Jul-2022


  • diabet mellitus type 2
  • statin (HMG-CoA reductase inhibitor)
  • medication adherance
  • medication possesion ratio
  • LDL-cholesterol
  • cholesterol
  • lipid lowering medication
  • LDL cholesterol targets
  • RISK

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