TY - JOUR
T1 - Adherence to Statin Therapy and Attainment of LDL Cholesterol Targets in an Outpatient Population of Type 2 Diabetes Patients
T2 - Analysis in the DIAbetes and LifEstyle Cohort Twente (DIALECT)
AU - Beernink, Jelle M.
AU - Oosterwijk, Milou M.
AU - van Boven, Job F. M.
AU - Heerspink, Hiddo J. L.
AU - Bakker, Stephan J. L.
AU - Navis, Gerjan
AU - Nijboer, Roos M.
AU - Gant, Christina M.
AU - Haverkate, Heleen
AU - Kruik-Kolloffel, Willemien J.
AU - Laverman, Gozewijn D.
PY - 2022/7/12
Y1 - 2022/7/12
N2 - Objective: To assess adherence to statin therapy and its association with sociodemographic data, medical characteristics, LDLc levels, and LDLc target attainment in real-world T2D patients treated in secondary care.Research Design and Methods: Cross-sectional analyses were performed on baseline data of 393 patients in the DIAbetes and LifEstyle Cohort Twente (DIALECT). The medication possession ratio (MPR), calculated with pharmacy dispensing data, was used to determine adherence to statins for an intended period of 24 months. Statins were included in the analyses if they were used for at least six consecutive months with at least three dispenses. Adherence was defined as an MPR >= 80%. Associations with adherence were assessed using descriptive statistics and binary logistic regression.Results: Overall, 80% of the patients had a statin prescription and of those, 89% were adherent. The proportion of patients who reached LDLc targets of
AB - Objective: To assess adherence to statin therapy and its association with sociodemographic data, medical characteristics, LDLc levels, and LDLc target attainment in real-world T2D patients treated in secondary care.Research Design and Methods: Cross-sectional analyses were performed on baseline data of 393 patients in the DIAbetes and LifEstyle Cohort Twente (DIALECT). The medication possession ratio (MPR), calculated with pharmacy dispensing data, was used to determine adherence to statins for an intended period of 24 months. Statins were included in the analyses if they were used for at least six consecutive months with at least three dispenses. Adherence was defined as an MPR >= 80%. Associations with adherence were assessed using descriptive statistics and binary logistic regression.Results: Overall, 80% of the patients had a statin prescription and of those, 89% were adherent. The proportion of patients who reached LDLc targets of
KW - diabet mellitus type 2
KW - statin (HMG-CoA reductase inhibitor)
KW - medication adherance
KW - medication possesion ratio
KW - LDL-cholesterol
KW - cholesterol
KW - lipid lowering medication
KW - LDL cholesterol targets
KW - CARDIOVASCULAR-DISEASE
KW - PRIMARY PREVENTION
KW - HEART-DISEASE
KW - RISK
KW - INTERVENTIONS
KW - MELLITUS
U2 - 10.3389/fphar.2022.888110
DO - 10.3389/fphar.2022.888110
M3 - Article
SN - 1663-9812
VL - 13
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 888110
ER -