Advanced glycation endproducts in chronic heart failure

Andries J. Smit*, Jasper W. L. Hartog, Adriaan A. Voors, Dirk J. van Veldhuisen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

35 Citations (Scopus)

Abstract

Advanced glycation endproducts (AGEs) have been proposed as factors involved in the development and progression of chronic heart failure (CHF). Cross-linking by AGEs results in vascular and myocardial stiffening, which are hallmarks in the pathogenesis of CHE Additionally, stimulation of receptors by AGEs may affect endothelial function and myocardial calcium uptake and may perpetuate coronary sclerosis in CHE CHF is common in conditions with AGE accumulation, such as diabetes and renal failure. This review describes in detail the interrelation of plasma AGEs, renal function, and the severity and prognosis in clinical CHF patients with mild to moderate loss of renal function. This association is compared with the relation between tissue AGE accumulation (marked by skin autofluorescence) and diastolic dysfunction in renal failure. The evidence reviewed here provides support for the assumed role of AGES in determining the severity and prognosis of CHF, but also highlights the differences in this relation between plasma and tissue AGEs and between patients with and without advanced renal failure. Ongoing clinical intervention trials to reduce AGE accumulation in patients with CHF may elucidate the causal role of AGEs in the development and course of CHE

Original languageEnglish
Title of host publicationMAILLARD REACTION: RECENT ADVANCES IN FOOD AND BIOMEDICAL SCIENCES
EditorsE Schleicher, Somoza, P Shieberle
Place of PublicationOXFORD
PublisherBlackwell Publishing
Pages225-230
Number of pages6
ISBN (Print)978-1-57331-719-1
DOIs
Publication statusPublished - 2008
Event9th International Symposium on the Maillard Reaction - , Germany
Duration: 1-Sep-2007 → …

Publication series

NameANNALS OF THE NEW YORK ACADEMY OF SCIENCES
PublisherBLACKWELL PUBLISHING
Volume1126
ISSN (Print)0077-8923

Other

Other9th International Symposium on the Maillard Reaction
CountryGermany
Period01/09/2007 → …

Keywords

  • heart failure
  • advanced glycation endproducts
  • renal function
  • CROSS-LINK BREAKER
  • END-PRODUCTS
  • DIABETIC CARDIOMYOPATHY
  • HEMODIALYSIS-PATIENTS
  • SKIN AUTOFLUORESCENCE
  • PREDICTS MORTALITY
  • DIASTOLIC FUNCTION
  • PROGNOSTIC VALUE
  • SERUM-LEVELS
  • ACCUMULATION

Cite this