Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity

Pien A Goldsteen, Amalia M Dolga, Reinoud Gosens*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The peripheral nervous system (PNS) plays crucial roles in physiology and disease. Neuro-effector communication and neuroplasticity of the PNS are poorly studied, since suitable models are lacking. The emergence of human pluripotent stem cells (hPSCs) has great promise to resolve this deficit. hPSC-derived PNS neurons, integrated into organ-on-a-chip systems or organoid cultures, allow co-cultures with cells of the local microenvironment to study neuro-effector interactions and to probe mechanisms underlying neuroplasticity.

Original languageEnglish
Pages (from-to)348-357
Number of pages10
JournalPhysiology
Volume35
Issue number5
DOIs
Publication statusPublished - Sep-2020

Keywords

  • neuroplasticity
  • human pluripotent stem cells
  • peripheral neurons
  • organ-on-a-chip
  • organoids
  • NEURAL CREST CELLS
  • PLURIPOTENT STEM-CELLS
  • SENSORY NEURONS
  • SYMPATHETIC NEURONS
  • NERVOUS-SYSTEM
  • INNERVATION
  • SKIN
  • NEUROPLASTICITY
  • NEUROTROPHINS
  • MECHANISMS

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