Advances in the development of entry inhibitors for sialic-acid-targeting viruses

Rick Heida, Yoshita C Bhide, Matteo Gasbarri, Özgün Kocabiyik, Francesco Stellacci, Anke L W Huckriede, Wouter L J Hinrichs*, Henderik W Frijlink

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)
110 Downloads (Pure)


Over the past decades, several antiviral drugs have been developed to treat a range of infections. Yet the number of treatable viral infections is still limited, and resistance to current drug regimens is an ever-growing problem. Therefore, additional strategies are needed to provide a rapid cure for infected individuals. An interesting target for antiviral drugs is the process of viral attachment and entry into the cell. Although most viruses use distinct host receptors for attachment to the target cell, some viruses share receptors, of which sialic acids are a common example. This review aims to give an update on entry inhibitors for a range of sialic-acid-targeting viruses and provides insight into the prospects for those with broad-spectrum potential.

Original languageEnglish
Pages (from-to)122-137
Number of pages16
JournalDrug Discovery Today
Issue number1
Early online date2020
Publication statusPublished - Jan-2021

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