Advances of epigenetic editing

Rutger A F Gjaltema, Marianne G Rots*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)
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Abstract

Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume57
Early online date29-Jun-2020
DOIs
Publication statusPublished - Aug-2020

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