Advances of epigenetic editing

Rutger A F Gjaltema; Marianne G Rots

doi:10.1016/j.cbpa.2020.04.020

Advances of epigenetic editing

Rutger A F Gjaltema, Marianne G Rots^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

1 Citation (Scopus)

60 Downloads (Pure)

Abstract

Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

Original language	English
Pages (from-to)	75-81
Number of pages	7
Journal	Current Opinion in Chemical Biology
Volume	57
Early online date	29-Jun-2020
DOIs	https://doi.org/10.1016/j.cbpa.2020.04.020
Publication status	Published - Aug-2020

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10.1016/j.cbpa.2020.04.020Licence: CC BY

Advances of epigenetic editingFinal publisher's version, 0.99 MBLicence: CC BY

Cite this

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title = "Advances of epigenetic editing",

abstract = "Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.",

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AU - Rots, Marianne G

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AB - Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

U2 - 10.1016/j.cbpa.2020.04.020

DO - 10.1016/j.cbpa.2020.04.020

M3 - Review article

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VL - 57

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JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

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