Abstract
Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.
Original language | English |
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Pages (from-to) | 75-81 |
Number of pages | 7 |
Journal | Current Opinion in Chemical Biology |
Volume | 57 |
Early online date | 29-Jun-2020 |
DOIs | |
Publication status | Published - Aug-2020 |