Advances of epigenetic editing

Rutger A F Gjaltema; Marianne G Rots

doi:10.1016/j.cbpa.2020.04.020

Advances of epigenetic editing

Rutger A F Gjaltema
, Marianne G Rots^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

96 Citations (Scopus)

641 Downloads (Pure)

Abstract

Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

Original language	English
Pages (from-to)	75-81
Number of pages	7
Journal	Current Opinion in Chemical Biology
Volume	57
Early online date	29-Jun-2020
DOIs	https://doi.org/10.1016/j.cbpa.2020.04.020
Publication status	Published - Aug-2020

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title = "Advances of epigenetic editing",

abstract = "Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.",

author = "Gjaltema, \{Rutger A F\} and Rots, \{Marianne G\}",

year = "2020",

month = aug,

doi = "10.1016/j.cbpa.2020.04.020",

language = "English",

volume = "57",

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publisher = "ELSEVIER SCI LTD",

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T1 - Advances of epigenetic editing

AU - Gjaltema, Rutger A F

AU - Rots, Marianne G

PY - 2020/8

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N2 - Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

AB - Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

U2 - 10.1016/j.cbpa.2020.04.020

DO - 10.1016/j.cbpa.2020.04.020

M3 - Review article

C2 - 32619853

SN - 1367-5931

VL - 57

SP - 75

EP - 81

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

ER -

Advances of epigenetic editing

Abstract

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