Advancing transcriptome analysis in models of disease and ageing

Tristan Vincent de Jong

    Research output: ThesisThesis fully internal (DIV)

    575 Downloads (Pure)

    Abstract

    RNA-sequencing technologies allow us to peak behind the curtain of biomolecular mechanisms which drive all known life on earth. The process of RNA synthesis is influenced by many factors, both intrinsic and extrinsic, on both micro and macro scales. In most RNA-sequencing experiments a component of a genetic pathway is manipulated after which changes on RNA abundances are investigated. In this thesis we examplify multiple RNA-sequencing experiments and reveal the dynamic range of information which can be taken from different experimental conditions using a rich toolbox of analytical methods.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Guryev, Victor, Supervisor
    • Nollen, Ellen, Supervisor
    • Williams, R.W., Assessment committee, External person
    • de Haan, Gerald, Assessment committee
    • Rots, Marianne, Assessment committee
    Award date28-Oct-2019
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-2051-6
    Electronic ISBNs978-94-034-1954-1
    DOIs
    Publication statusPublished - 2019

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