Age-dependent modulation of motor network connectivity for skill acquisition, consolidation and interlimb transfer after motor practice

M. P. Veldman*, N. M. Maurits, D. Mantini, T. Hortobagyi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: Age-related differences in neural strategies for motor learning are not fully understood. We determined the effects of age on the relationship between motor network connectivity and motor skill acquisition, consolidation, and interlimb transfer using dynamic imaging of coherent sources.

Methods: Healthy younger (n = 24, 18-24 y) and older (n = 24, 65-87 y) adults unilaterally practiced a visuomotor task and resting-state electroencephalographic data was acquired before and after practice as well as at retention.

Results: The results showed that right-hand skill acquisition and consolidation did not differ between age groups. However, age affected the ability to transfer the newly acquired motor skill to the non-practiced limb. Moreover, strengthened left- and right-primary motor cortex-related beta conectivity was negatively and positively associated with right-hand skill acquisition and left-hand skill consolidation in older adults, respectively.

Conclusion: Age-dependent modulations of bilateral resting-state motor network connectivity indicate age-specific strategies for the acquisition, consolidation, and interlimb transfer of novel motor tasks.

Significance: The present results provide insights into the mechanisms underlying motor learning that are important for the development of interventions for patients with unilateral injuries. (C) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1790-1801
Number of pages12
JournalClinical Neurophysiology
Volume132
Issue number8
DOIs
Publication statusPublished - Aug-2021

Keywords

  • Aging
  • Dynamic imaging of coherent sources
  • Electroencephalography
  • Motor learning
  • CROSS-LIMB TRANSFER
  • FUNCTIONAL CONNECTIVITY
  • BIMANUAL COORDINATION
  • INTERMANUAL TRANSFER
  • PERFORMANCE GAINS
  • BRAIN-REGIONS
  • OLDER-ADULTS
  • SHORT-TERM
  • PLASTICITY
  • EDUCATION

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