Age-related myelin degradation burdens the clearance function of microglia during aging

Shima Safaiyan; Nirmal Kannaiyan; Nicolas Snaidero; Simone Brioschi; Knut Biber; Simon Yona; Aimee L. Edinger; Steffen Jung; Moritz J. Rossner; Mikael Simons

doi:10.1038/nn.4325

Age-related myelin degradation burdens the clearance function of microglia during aging

Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi, Knut Biber, Simon Yona, Aimee L. Edinger, Steffen Jung, Moritz J. Rossner, Mikael Simons^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

400 Citations (Scopus)

Abstract

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

Original language	English
Pages (from-to)	995-998
Number of pages	4
Journal	Nature neuroscience
Volume	19
Issue number	8
DOIs	https://doi.org/10.1038/nn.4325
Publication status	Published - 13-Jun-2016

Keywords

NERVOUS-SYSTEM
CNS
BRAIN
CELLS
MICE
DYNAMICS
DEMYELINATION
DELETION
TISSUE

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Age-related myelin degradation burdens the clearance function of microglia
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title = "Age-related myelin degradation burdens the clearance function of microglia during aging",

abstract = "Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.",

keywords = "NERVOUS-SYSTEM, CNS, BRAIN, CELLS, MICE, DYNAMICS, DEMYELINATION, DELETION, TISSUE",

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AU - Safaiyan, Shima

AU - Kannaiyan, Nirmal

AU - Snaidero, Nicolas

AU - Brioschi, Simone

AU - Biber, Knut

AU - Yona, Simon

AU - Edinger, Aimee L.

AU - Jung, Steffen

AU - Rossner, Moritz J.

AU - Simons, Mikael

PY - 2016/6/13

Y1 - 2016/6/13

N2 - Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

AB - Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

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KW - CNS

KW - BRAIN

KW - CELLS

KW - MICE

KW - DYNAMICS

KW - DEMYELINATION

KW - DELETION

KW - TISSUE

U2 - 10.1038/nn.4325

DO - 10.1038/nn.4325

M3 - Article

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VL - 19

SP - 995

EP - 998

JO - Nature neuroscience

JF - Nature neuroscience

IS - 8

ER -

Age-related myelin degradation burdens the clearance function of microglia during aging

Abstract

Keywords

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