Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype

Allard J. Hauer; Ynte M. Ruigrok; Ale Algra; Ewoud J. van Dijk; Peter J. Koudstaal; Gert-Jan Luijckx; Paul J. Nederkoorn; Robert J. van Oostenbrugge; Marieke C. Visser; Marieke J. Wermer; L. Jaap Kappelle; Catharina J. M. Klijn; Dutch Parelsnoer Inst-Cerebrovasc

doi:10.1161/JAHA.116.005090

Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype

Allard J. Hauer, Ynte M. Ruigrok, Ale Algra, Ewoud J. van Dijk, Peter J. Koudstaal, Gert-Jan Luijckx, Paul J. Nederkoorn, Robert J. van Oostenbrugge, Marieke C. Visser, Marieke J. Wermer, L. Jaap Kappelle, Catharina J. M. Klijn^*, Dutch Parelsnoer Inst-Cerebrovasc

^*Corresponding author for this work

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Abstract

Background--Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age.

5Methods and Results--We studied a prospective multicenter university hospital-based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or aneurysmal subarachnoid hemorrhage, we calculated prevalences of vascular risk factors in 4 age groups: = 75 years, and mean differences with 95% CIs in relation to the reference age group. Patients aged

Conclusions--The prevalence of common cardiovascular risk factors shows different age-specific patterns among various stroke subtypes. Recognition of these patterns may guide tailored stroke prevention efforts aimed at specific risk groups.

Original language	English
Article number	e005090
Number of pages	25
Journal	Journal of the American Heart Association
Volume	6
DOIs	https://doi.org/10.1161/JAHA.116.005090
Publication status	Published - 8-May-2017

Keywords

cerebrovascular disease/stroke
intracerebral hemorrhage
ischemic stroke
risk factor
subarachnoid hemorrhage
1ST-EVER ISCHEMIC-STROKE
INTRACEREBRAL HEMORRHAGE
SUBARACHNOID HEMORRHAGE
SYSTEMATIC ANALYSIS
GLOBAL BURDEN
YOUNG STROKE
POPULATION
DISEASE
ADULTS
OLD

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Age‐Specific Vascular Risk Factor Profiles According to Stroke SubtypeFinal publisher's version, 2 MBLicence: CC BY-NC

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Hauer, A. J., Ruigrok, Y. M., Algra, A., van Dijk, E. J., Koudstaal, P. J., Luijckx, G.-J., Nederkoorn, P. J., van Oostenbrugge, R. J., Visser, M. C., Wermer, M. J., Kappelle, L. J., Klijn, C. J. M., & Dutch Parelsnoer Inst-Cerebrovasc (2017). Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype. Journal of the American Heart Association, 6, Article e005090. https://doi.org/10.1161/JAHA.116.005090

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title = "Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype",

abstract = "Background--Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age.5Methods and Results--We studied a prospective multicenter university hospital-based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or aneurysmal subarachnoid hemorrhage, we calculated prevalences of vascular risk factors in 4 age groups: = 75 years, and mean differences with 95% CIs in relation to the reference age group. Patients agedConclusions--The prevalence of common cardiovascular risk factors shows different age-specific patterns among various stroke subtypes. Recognition of these patterns may guide tailored stroke prevention efforts aimed at specific risk groups.",

keywords = "cerebrovascular disease/stroke, intracerebral hemorrhage, ischemic stroke, risk factor, subarachnoid hemorrhage, 1ST-EVER ISCHEMIC-STROKE, INTRACEREBRAL HEMORRHAGE, SUBARACHNOID HEMORRHAGE, SYSTEMATIC ANALYSIS, GLOBAL BURDEN, YOUNG STROKE, POPULATION, DISEASE, ADULTS, OLD",

author = "Hauer, {Allard J.} and Ruigrok, {Ynte M.} and Ale Algra and {van Dijk}, {Ewoud J.} and Koudstaal, {Peter J.} and Gert-Jan Luijckx and Nederkoorn, {Paul J.} and {van Oostenbrugge}, {Robert J.} and Visser, {Marieke C.} and Wermer, {Marieke J.} and Kappelle, {L. Jaap} and Klijn, {Catharina J. M.} and {Dutch Parelsnoer Inst-Cerebrovasc}",

year = "2017",

month = may,

day = "8",

doi = "10.1161/JAHA.116.005090",

language = "English",

volume = "6",

journal = "Journal of the American Heart Association",

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Hauer, AJ, Ruigrok, YM, Algra, A, van Dijk, EJ, Koudstaal, PJ, Luijckx, G-J, Nederkoorn, PJ, van Oostenbrugge, RJ, Visser, MC, Wermer, MJ, Kappelle, LJ, Klijn, CJM & Dutch Parelsnoer Inst-Cerebrovasc 2017, 'Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype', Journal of the American Heart Association, vol. 6, e005090. https://doi.org/10.1161/JAHA.116.005090

TY - JOUR

T1 - Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype

AU - Hauer, Allard J.

AU - Ruigrok, Ynte M.

AU - Algra, Ale

AU - van Dijk, Ewoud J.

AU - Koudstaal, Peter J.

AU - Luijckx, Gert-Jan

AU - Nederkoorn, Paul J.

AU - van Oostenbrugge, Robert J.

AU - Visser, Marieke C.

AU - Wermer, Marieke J.

AU - Kappelle, L. Jaap

AU - Klijn, Catharina J. M.

AU - Dutch Parelsnoer Inst-Cerebrovasc

PY - 2017/5/8

Y1 - 2017/5/8

N2 - Background--Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age.5Methods and Results--We studied a prospective multicenter university hospital-based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or aneurysmal subarachnoid hemorrhage, we calculated prevalences of vascular risk factors in 4 age groups: = 75 years, and mean differences with 95% CIs in relation to the reference age group. Patients agedConclusions--The prevalence of common cardiovascular risk factors shows different age-specific patterns among various stroke subtypes. Recognition of these patterns may guide tailored stroke prevention efforts aimed at specific risk groups.

AB - Background--Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age.5Methods and Results--We studied a prospective multicenter university hospital-based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or aneurysmal subarachnoid hemorrhage, we calculated prevalences of vascular risk factors in 4 age groups: = 75 years, and mean differences with 95% CIs in relation to the reference age group. Patients agedConclusions--The prevalence of common cardiovascular risk factors shows different age-specific patterns among various stroke subtypes. Recognition of these patterns may guide tailored stroke prevention efforts aimed at specific risk groups.

KW - cerebrovascular disease/stroke

KW - intracerebral hemorrhage

KW - ischemic stroke

KW - risk factor

KW - subarachnoid hemorrhage

KW - 1ST-EVER ISCHEMIC-STROKE

KW - INTRACEREBRAL HEMORRHAGE

KW - SUBARACHNOID HEMORRHAGE

KW - SYSTEMATIC ANALYSIS

KW - GLOBAL BURDEN

KW - YOUNG STROKE

KW - POPULATION

KW - DISEASE

KW - ADULTS

KW - OLD

U2 - 10.1161/JAHA.116.005090

DO - 10.1161/JAHA.116.005090

M3 - Article

C2 - 28483775

SN - 2047-9980

VL - 6

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

M1 - e005090

ER -

Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype

Abstract

Keywords

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