Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

Carolien M. Woolthuis; Gerald de Haan; Gerwin Huls

doi:10.1016/j.coi.2011.05.006

Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

Carolien M. Woolthuis, Gerald de Haan, Gerwin Huls^*

^*Corresponding author for this work

University of Groningen

Research output: Contribution to journal › Review article › peer-review

52 Citations (Scopus)

Abstract

During development hematopoietic stem cells (HSCs) expand in number and persist throughout life by undergoing self-renewing divisions. Nevertheless, the hematopoietic system does not escape the negative effects of aging, suggesting that self-renewal is not complete. A fundamental issue in stem cell biology relates to such age-dependent loss of stem cell activity. Both stem cell intrinsic factors and extrinsic factors associated with an aging micro-environment could contribute to aging of the hematopoietic system. Recently, changes in the clonal composition of the HSC compartment during aging have been put forward as a key factor. Here, we discuss these recent developments and speculate how they may be of clinical relevance.

Original language	English
Pages (from-to)	512-517
Number of pages	6
Journal	Current opinion in immunology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.coi.2011.05.006
Publication status	Published - Aug-2011

Keywords

AGE-RELATED-CHANGES
ACUTE MYELOID-LEUKEMIA
BONE-MARROW
PROGENITOR CELLS
COMPARTMENT
NICHE
MICE
IMMUNOSENESCENCE
PROLIFERATION
REJUVENATION

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@article{58e550a9e90f4bc283060e0097f7c025,

title = "Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?",

abstract = "During development hematopoietic stem cells (HSCs) expand in number and persist throughout life by undergoing self-renewing divisions. Nevertheless, the hematopoietic system does not escape the negative effects of aging, suggesting that self-renewal is not complete. A fundamental issue in stem cell biology relates to such age-dependent loss of stem cell activity. Both stem cell intrinsic factors and extrinsic factors associated with an aging micro-environment could contribute to aging of the hematopoietic system. Recently, changes in the clonal composition of the HSC compartment during aging have been put forward as a key factor. Here, we discuss these recent developments and speculate how they may be of clinical relevance.",

keywords = "AGE-RELATED-CHANGES, ACUTE MYELOID-LEUKEMIA, BONE-MARROW, PROGENITOR CELLS, COMPARTMENT, NICHE, MICE, IMMUNOSENESCENCE, PROLIFERATION, REJUVENATION",

author = "Woolthuis, {Carolien M.} and {de Haan}, Gerald and Gerwin Huls",

year = "2011",

month = aug,

doi = "10.1016/j.coi.2011.05.006",

language = "English",

volume = "23",

pages = "512--517",

journal = "Current opinion in immunology",

issn = "0952-7915",

number = "4",

}

TY - JOUR

T1 - Aging of hematopoietic stem cells

T2 - Intrinsic changes or micro-environmental effects?

AU - Woolthuis, Carolien M.

AU - de Haan, Gerald

AU - Huls, Gerwin

PY - 2011/8

Y1 - 2011/8

N2 - During development hematopoietic stem cells (HSCs) expand in number and persist throughout life by undergoing self-renewing divisions. Nevertheless, the hematopoietic system does not escape the negative effects of aging, suggesting that self-renewal is not complete. A fundamental issue in stem cell biology relates to such age-dependent loss of stem cell activity. Both stem cell intrinsic factors and extrinsic factors associated with an aging micro-environment could contribute to aging of the hematopoietic system. Recently, changes in the clonal composition of the HSC compartment during aging have been put forward as a key factor. Here, we discuss these recent developments and speculate how they may be of clinical relevance.

AB - During development hematopoietic stem cells (HSCs) expand in number and persist throughout life by undergoing self-renewing divisions. Nevertheless, the hematopoietic system does not escape the negative effects of aging, suggesting that self-renewal is not complete. A fundamental issue in stem cell biology relates to such age-dependent loss of stem cell activity. Both stem cell intrinsic factors and extrinsic factors associated with an aging micro-environment could contribute to aging of the hematopoietic system. Recently, changes in the clonal composition of the HSC compartment during aging have been put forward as a key factor. Here, we discuss these recent developments and speculate how they may be of clinical relevance.

KW - AGE-RELATED-CHANGES

KW - ACUTE MYELOID-LEUKEMIA

KW - BONE-MARROW

KW - PROGENITOR CELLS

KW - COMPARTMENT

KW - NICHE

KW - MICE

KW - IMMUNOSENESCENCE

KW - PROLIFERATION

KW - REJUVENATION

U2 - 10.1016/j.coi.2011.05.006

DO - 10.1016/j.coi.2011.05.006

M3 - Review article

SN - 0952-7915

VL - 23

SP - 512

EP - 517

JO - Current opinion in immunology

JF - Current opinion in immunology

IS - 4

ER -

Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

Abstract

Keywords

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