Agonist effects at putative central 5-HT4receptors in rat hippocampus by R(+)- and S(-)-zacopride; no evidence for stereo-selectivity

H.W.G.M. Boddeke, H.O. Kalkman

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The EEG of halothane anaesthetized rats was recorded from an electrode implanted into the hippocampus. In the present study the effect of R(+)- and S(-)-zacopride, administered intra-cerebroventricularly, on different frequency bands of the EEG was investigated. Both enantiomers induced similar dose-dependent (5-20 μg) increases in all frequency bands. The effects of R(+)- and S(-)-zacopride were inhibited by pretreatment with a high dose of ICS 205-930 (1 μg i.c.v.), which suggests the involvement of 5-HT4receptors. The lack of stereo-selectivity of the zacopride enantiomers is in contrast to observations made in in vitro studies.
Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 12-Nov-1992


  • 5-hydroxytryptamine4receptor
  • EEG activity
  • zacopride enantiomer
  • serotonin antagonist
  • serotonin receptor
  • tropisetron
  • zacopride
  • animal experiment
  • article
  • electroencephalography
  • enantiomer
  • hippocampus
  • intracerebroventricular drug administration
  • male
  • nonhuman
  • priority journal
  • rat

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