The operations of the superconducting cyclotron AGOR over the past years will be reviewed. Reliability issues encountered after nearly 25 years of operation and mitigation measures to warrant reliable operation for the coming decade will be discussed. The research performed with AGOR has significantly shifted from fundamental physics to radiation biology and medical radiation physics, both in collaboration with the Groningen Proton Therapy Center, and radiation hardness studies. The radiation biology research will be substantially expanded in the coming years with a new beam line for image guided preclinical research. For this research new dose delivery modalities including scanning, spatial fractionation and very high dose rates are developed. In addition, a new program has been started on the production of exotic nuclei, for which a new superconducting solenoid fragment separator will be developed. For the radiation hardness testing a cocktail beam at 30 MeV/amu with several ion species up to Xe has been developed and is now routinely delivered for experiments. A cocktail at 15 MeV/amu up to Bi is under development.