Air pollution and IgE sensitization in 4 European birth cohorts-the MeDALL project

Erik Melen, Marie Standl, Ulrike Gehring, Hicran Altug, Josep Maria Anto, Dietrich Berdel, Anna Bergstrom, Jean Bousquet, Joachim Heinrich, Gerard H. Koppelman, Inger Kull, Christian Lupinek, Iana Markevych, Tamara Schikowski, Elisabeth Thiering, Rudolf Valenta, Marianne van Hage, Andrea von Berg, Judith M. Vonk, Magnus WickmanAlet Wijga, Olena Gruzieva*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: Whether long-term exposure air to pollution has effects on allergic sensitization is controversial.

Objective: Our aim was to investigate associations of air pollution exposure at birth and at the time of later biosampling with IgE sensitization against common food and inhalant allergens, or specific allergen molecules, in children aged up to 16 years.

Methods: A total of 6163 children from 4 European birth cohorts participating in the Mechanisms of the Development of ALLergy [MeDALL] consortium were included in this meta-analysis of the following studies: Children, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) (Sweden), Influences of Lifestyle-Related Factors on the Human Immune System and Development of Allergies in Childhood (LISA)/German Infant Study on the Influence of Nutrition Intervention PLUS Environmental and Genetic Influences on Allergy Development (GINIplus) (Germany), and Prevention and Incidence of Asthma and Mite Allergy (PIAMA) (The Netherlands). The following indicators were modeled by land use regression: individual residential outdoor levels of particulate matter with aerodynamic diameters less than 2.5 mu m, less than 10 mu m, and between 2.5 and 10 mu m; PM2.5 absorbance (a measurement of the blackness of PM2.5 filters); and nitrogen oxides levels. Blood samples drawn at ages 4 to 6 (n = 5989), 8 to 10 (n = 6603), and 15 to 16 (n = 5825) years were analyzed for IgE sensitization to allergen extracts by ImmunoCAP. Additionally, IgE against 132 allergen molecules was measured by using the MedALL microarray chip (n = 1021).

Results: Air pollution was not consistently associated with IgE sensitization to any common allergen extract up to age 16 years. However, allergen-specific analyses suggested increased risks of sensitization to birch (odds ratio [OR] = 1.12 [95% CI = 1.01-1.25] per 10-mu g/m(3) increase in NO2 exposure). In a subpopulation with microarray data, IgE to the major timothy grass allergen Phleum pratense 1 (Phl p 1) and the cat allergen Felis domesticus 1 (Fel d 1) greater than 3.5 Immuno Solid-phase Allergen Chip standardized units for detection of IgE antibodies were related to PM2.5 exposure at birth (OR = 3.33 [95% CI = 1.40-7.94] and OR = 4.98 [95% CI = 1.59-15.60], respectively, per 5-mu g/m(3) increase in exposure).

Conclusion: Air pollution exposure does not seem to increase the overall risk of allergic sensitization; however, sensitization to birch as well as grass pollen Phl p 1 and cat Fel d 1 allergen molecules may be related to specific pollutants.

Original languageEnglish
Pages (from-to)713-722
Number of pages10
JournalJournal of Allergy and Clinical Immunology
Volume147
Issue number2
Early online date11-Sep-2020
DOIs
Publication statusPublished - Feb-2021

Keywords

  • Allergy
  • allergen
  • air pollution
  • children
  • cohort
  • IgE
  • sensitization
  • meta-analysis

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