Airway granulation response to lung-implantable medical devices: a concise overview

Sharyn A. Roodenburg*, Simon D. Pouwels, Dirk-Jan Slebos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
55 Downloads (Pure)

Abstract

Increasing numbers of endoscopically implantable devices are implanted in the airways, such as airway stents, one-way valves and coils, to treat both malignant and benign diseases. They significantly improve patient outcomes, but their long-term effectiveness and sustainability is hampered by the reaction of the formation of granulation tissue. Factors including procedural-related tissue injury; micro-organism presence; device-related factors, such as the material, design and sizing in relation to the airway; and patient-related factors, including genetic susceptibility, comorbidities and medication use, might all effect the severity of the tissue response and the subsequent degree of granulation tissue formation. However, research into the underlying mechanism and risk factors is scarce and therefore our knowledge is limited. Joint efforts from the scientific community, both pre-clinical and clinical, are needed to gain a deeper understanding and eventually improve the long-term treatment effectiveness of lung-implantable devices.

Original languageEnglish
Article number210066
Number of pages7
JournalEuropean Respiratory Review
Volume30
Issue number161
DOIs
Publication statusPublished - 30-Sept-2021

Keywords

  • FOREIGN-BODY REACTION
  • TISSUE FORMATION
  • VOLUME REDUCTION
  • SEVERE EMPHYSEMA
  • STENTS
  • SUSCEPTIBILITY
  • BRONCHOSCOPY
  • INFLAMMATION
  • STRICTURES
  • IMMUNITY

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