Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients

Dorien M. Zelle; Pramod K. Agarwal; Jessica L. Pinto Ramirez; Jaap J. Homan van der Heide; Eva Corpeleijn; Reinold O. B. Gans; Gerjan Navis; Stephan J. L. Bakker

doi:10.1097/TP.0b013e318222ca10

Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients

Dorien M. Zelle^*, Pramod K. Agarwal, Jessica L. Pinto Ramirez, Jaap J. Homan van der Heide, Eva Corpeleijn, Reinold O. B. Gans, Gerjan Navis, Stephan J. L. Bakker

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

Background. Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.

Method. RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.

Results. Six hundred RTR were studied (age 51 +/- 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR=0.36 [0.2-0.6], P=

Conclusions. Moderate alcohol consumption is associated with low prevalence of NODAT and reduced risk for mortality in RTR, in line with findings in the general population. These findings refute the common advice to refrain from alcohol in RTR.

Original language	English
Pages (from-to)	203-209
Number of pages	7
Journal	Transplantation
Volume	92
Issue number	2
DOIs	https://doi.org/10.1097/TP.0b013e318222ca10
Publication status	Published - 27-Jul-2011

Keywords

Renal transplantation
Alcohol consumption
Mortality
New onset of diabetes after transplantation
CORONARY-HEART-DISEASE
CHRONIC KIDNEY-DISEASE
MYOCARDIAL-INFARCTION
CARDIOVASCULAR-DISEASE
DENSITY-LIPOPROTEIN
INSULIN SENSITIVITY
DRINKING PATTERN
ISCHEMIC-STROKE
BLOOD-PRESSURE
LOWER RISK

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10.1097/TP.0b013e318222ca10

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Alcohol_Consumption,_New_Onset_of_Diabetes_After.14
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Bakker, S. (Creator), Leuvenink, H. (Creator) & Porte, R. (Creator), University of Groningen, 2017
http://www.transplantlines.umcg.nl
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@article{da121b386e794ce294c6550198097816,

title = "Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients",

abstract = "Background. Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.Method. RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.Results. Six hundred RTR were studied (age 51 +/- 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR=0.36 [0.2-0.6], P=Conclusions. Moderate alcohol consumption is associated with low prevalence of NODAT and reduced risk for mortality in RTR, in line with findings in the general population. These findings refute the common advice to refrain from alcohol in RTR.",

keywords = "Renal transplantation, Alcohol consumption, Mortality, New onset of diabetes after transplantation, CORONARY-HEART-DISEASE, CHRONIC KIDNEY-DISEASE, MYOCARDIAL-INFARCTION, CARDIOVASCULAR-DISEASE, DENSITY-LIPOPROTEIN, INSULIN SENSITIVITY, DRINKING PATTERN, ISCHEMIC-STROKE, BLOOD-PRESSURE, LOWER RISK",

author = "Zelle, {Dorien M.} and Agarwal, {Pramod K.} and Ramirez, {Jessica L. Pinto} and {van der Heide}, {Jaap J. Homan} and Eva Corpeleijn and Gans, {Reinold O. B.} and Gerjan Navis and Bakker, {Stephan J. L.}",

year = "2011",

month = jul,

day = "27",

doi = "10.1097/TP.0b013e318222ca10",

language = "English",

volume = "92",

pages = "203--209",

journal = "Transplantation",

issn = "0041-1337",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "2",

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Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients. / Zelle, Dorien M.; Agarwal, Pramod K.; Ramirez, Jessica L. Pinto; van der Heide, Jaap J. Homan; Corpeleijn, Eva ; Gans, Reinold O. B.; Navis, Gerjan ; Bakker, Stephan J. L.

In: Transplantation, Vol. 92, No. 2, 27.07.2011, p. 203-209.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients

AU - Zelle, Dorien M.

AU - Agarwal, Pramod K.

AU - Ramirez, Jessica L. Pinto

AU - van der Heide, Jaap J. Homan

AU - Corpeleijn, Eva

AU - Gans, Reinold O. B.

AU - Navis, Gerjan

AU - Bakker, Stephan J. L.

PY - 2011/7/27

Y1 - 2011/7/27

N2 - Background. Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.Method. RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.Results. Six hundred RTR were studied (age 51 +/- 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR=0.36 [0.2-0.6], P=Conclusions. Moderate alcohol consumption is associated with low prevalence of NODAT and reduced risk for mortality in RTR, in line with findings in the general population. These findings refute the common advice to refrain from alcohol in RTR.

AB - Background. Renal transplant recipients (RTR) are often advised to refrain from alcohol because of possible interaction with their immunosuppressive medication. Although moderate alcohol consumption is associated with reduced risk of diabetes and mortality in the general population, this is unknown for RTR. Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR.Method. RTR were investigated between 2001 and 2003. Alcohol consumption was assessed by self-report. Mortality and graft failure was recorded until May 2009.Results. Six hundred RTR were studied (age 51 +/- 12 years, 55% men). Of these RTR, 48% were abstainers, 38% had light alcohol intake, 13% had moderate intake, and 1% were heavy consumers. Moderate alcohol consumption was associated with a lower risk of developing NODAT over the follow-up period than was abstention (OR=0.36 [0.2-0.6], P=Conclusions. Moderate alcohol consumption is associated with low prevalence of NODAT and reduced risk for mortality in RTR, in line with findings in the general population. These findings refute the common advice to refrain from alcohol in RTR.

KW - Renal transplantation

KW - Alcohol consumption

KW - Mortality

KW - New onset of diabetes after transplantation

KW - CORONARY-HEART-DISEASE

KW - CHRONIC KIDNEY-DISEASE

KW - MYOCARDIAL-INFARCTION

KW - CARDIOVASCULAR-DISEASE

KW - DENSITY-LIPOPROTEIN

KW - INSULIN SENSITIVITY

KW - DRINKING PATTERN

KW - ISCHEMIC-STROKE

KW - BLOOD-PRESSURE

KW - LOWER RISK

U2 - 10.1097/TP.0b013e318222ca10

DO - 10.1097/TP.0b013e318222ca10

M3 - Article

VL - 92

SP - 203

EP - 209

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 2

ER -

Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients

Abstract

Keywords

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