Allergic contact dermatitis caused by 1,6-hexanediol diacrylate in a hospital wristband

Cynthia C. A. van Amerongen, Jakob Dahlin, Marlene Isaksson, Marie L. A. Schuttelaar*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer. Objectives To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband. Methods A male patient presented with eczema on his wrist where he had worn a hospital wristband. Patch testing was performed with our extended European baseline series, additional series, and pieces of the hospital wristband. Thin-layer chromatography (TLC) was performed with extracts from the wristband and gas chromatography-mass spectrometry was used for chemical analysis. Results Positive reactions were found to pieces of the wristband, including adhesive rim (+++), inside (+++), and outside (++); to multiple allergens in the (meth)acrylates series; and to extracts of the wristband in acetone and ethanol. Chemical analysis of the ethanol extract showed presence of lauryl acrylate and 1,6-HDDA. Patch testing with TLC strips and subsequent chemical analysis showed that the substance causing the strongest reaction was 1,6-HDDA, to which the patient had a confirmed positive patch test reaction. Conclusion 1,6-HDDA was identified as the culprit allergen responsible for allergic contact dermatitis caused by the hospital wristband.

Original languageEnglish
Pages (from-to)446-449
Number of pages4
Issue number6
Publication statusE-pub ahead of print - 7-Aug-2019


  • 1
  • 6-hexanediol diacrylate (1
  • 6-HDDA)
  • acrylate
  • allergic contact dermatitis
  • CAS no
  • 13048-33-4
  • case report
  • wristband

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