Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze

Marc P. van der Schee; Simone Hashimoto; Annemarie C. Schuurman; Janine S. Repelaer van Driel; Nora Adriaens; Romy M. van Amelsfoort; Tessa Snoeren; Martine Regenboog; Aline B. Sprikkelman; Eric G. Haarman; Wim M. C. van Aalderen; Peter J. Sterk

doi:10.1183/09031936.00044414

Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze

Marc P. van der Schee^*, Simone Hashimoto, Annemarie C. Schuurman, Janine S. Repelaer van Driel, Nora Adriaens, Romy M. van Amelsfoort, Tessa Snoeren, Martine Regenboog, Aline B. Sprikkelman, Eric G. Haarman, Wim M. C. van Aalderen, Peter J. Sterk

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

Preschool rhinovirus-induced wheeze is associated with an increased risk of asthma. In adult asthma, exhaled volatile organic compounds (VOC) are associated with inflammatory activity. We therefore hypothesised that acute preschool wheeze is accompanied by a differential profile of exhaled VOC, which is maintained after resolution of symptoms in those children with rhinovirus-induced wheeze.

We included 178 children (mean +/- SD age 22 +/- 9 months) from the EUROPA cohort comparing asymptomatic and wheezing children during respiratory symptoms and after recovery. Naso- and oropharyngeal swabs were tested for rhinovirus by quantitative PCR. Breath was collected via a spacer and analysed using an electronic nose. Between-group discrimination was assessed by constructing a 1000-fold cross-validated receiver operating characteristic curve. Analyses were stratified by rhinovirus presence/absence.

Wheezing children demonstrated a different VOC profile when compared with asymptomatic children (p

Exhaled molecular profiles differ between preschool children with and without acute respiratory wheeze. This appears to be sustained in children with rhinovirus-induced wheeze after resolution of symptoms. Therefore, exhaled VOC may qualify as candidate biomarkers for early signs of asthma.

Original language	English
Pages (from-to)	440-448
Number of pages	9
Journal	European Respiratory Journal
Volume	45
Issue number	2
DOIs	https://doi.org/10.1183/09031936.00044414
Publication status	Published - Feb-2015
Externally published	Yes

Keywords

VOLATILE ORGANIC-COMPOUNDS
1ST 6 YEARS
NITRIC-OXIDE
PRESCHOOL WHEEZERS
CHILDHOOD ASTHMA
VIRAL-INFECTIONS
ELECTRONIC NOSE
FOLLOW-UP
BREATH
LIFE

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Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze
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van der Schee, M. P., Hashimoto, S., Schuurman, A. C., van Driel, J. S. R., Adriaens, N., van Amelsfoort, R. M., Snoeren, T., Regenboog, M., Sprikkelman, A. B., Haarman, E. G., van Aalderen, W. M. C., & Sterk, P. J. (2015). Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze. European Respiratory Journal, 45(2), 440-448. https://doi.org/10.1183/09031936.00044414

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title = "Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze",

abstract = "Preschool rhinovirus-induced wheeze is associated with an increased risk of asthma. In adult asthma, exhaled volatile organic compounds (VOC) are associated with inflammatory activity. We therefore hypothesised that acute preschool wheeze is accompanied by a differential profile of exhaled VOC, which is maintained after resolution of symptoms in those children with rhinovirus-induced wheeze.We included 178 children (mean +/- SD age 22 +/- 9 months) from the EUROPA cohort comparing asymptomatic and wheezing children during respiratory symptoms and after recovery. Naso- and oropharyngeal swabs were tested for rhinovirus by quantitative PCR. Breath was collected via a spacer and analysed using an electronic nose. Between-group discrimination was assessed by constructing a 1000-fold cross-validated receiver operating characteristic curve. Analyses were stratified by rhinovirus presence/absence.Wheezing children demonstrated a different VOC profile when compared with asymptomatic children (pExhaled molecular profiles differ between preschool children with and without acute respiratory wheeze. This appears to be sustained in children with rhinovirus-induced wheeze after resolution of symptoms. Therefore, exhaled VOC may qualify as candidate biomarkers for early signs of asthma.",

keywords = "VOLATILE ORGANIC-COMPOUNDS, 1ST 6 YEARS, NITRIC-OXIDE, PRESCHOOL WHEEZERS, CHILDHOOD ASTHMA, VIRAL-INFECTIONS, ELECTRONIC NOSE, FOLLOW-UP, BREATH, LIFE",

author = "{van der Schee}, {Marc P.} and Simone Hashimoto and Schuurman, {Annemarie C.} and {van Driel}, {Janine S. Repelaer} and Nora Adriaens and {van Amelsfoort}, {Romy M.} and Tessa Snoeren and Martine Regenboog and Sprikkelman, {Aline B.} and Haarman, {Eric G.} and {van Aalderen}, {Wim M. C.} and Sterk, {Peter J.}",

year = "2015",

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doi = "10.1183/09031936.00044414",

language = "English",

volume = "45",

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van der Schee, MP, Hashimoto, S, Schuurman, AC, van Driel, JSR, Adriaens, N, van Amelsfoort, RM, Snoeren, T, Regenboog, M, Sprikkelman, AB, Haarman, EG, van Aalderen, WMC & Sterk, PJ 2015, 'Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze', European Respiratory Journal, vol. 45, no. 2, pp. 440-448. https://doi.org/10.1183/09031936.00044414

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T1 - Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze

AU - van der Schee, Marc P.

AU - Hashimoto, Simone

AU - Schuurman, Annemarie C.

AU - van Driel, Janine S. Repelaer

AU - Adriaens, Nora

AU - van Amelsfoort, Romy M.

AU - Snoeren, Tessa

AU - Regenboog, Martine

AU - Sprikkelman, Aline B.

AU - Haarman, Eric G.

AU - van Aalderen, Wim M. C.

AU - Sterk, Peter J.

PY - 2015/2

Y1 - 2015/2

N2 - Preschool rhinovirus-induced wheeze is associated with an increased risk of asthma. In adult asthma, exhaled volatile organic compounds (VOC) are associated with inflammatory activity. We therefore hypothesised that acute preschool wheeze is accompanied by a differential profile of exhaled VOC, which is maintained after resolution of symptoms in those children with rhinovirus-induced wheeze.We included 178 children (mean +/- SD age 22 +/- 9 months) from the EUROPA cohort comparing asymptomatic and wheezing children during respiratory symptoms and after recovery. Naso- and oropharyngeal swabs were tested for rhinovirus by quantitative PCR. Breath was collected via a spacer and analysed using an electronic nose. Between-group discrimination was assessed by constructing a 1000-fold cross-validated receiver operating characteristic curve. Analyses were stratified by rhinovirus presence/absence.Wheezing children demonstrated a different VOC profile when compared with asymptomatic children (pExhaled molecular profiles differ between preschool children with and without acute respiratory wheeze. This appears to be sustained in children with rhinovirus-induced wheeze after resolution of symptoms. Therefore, exhaled VOC may qualify as candidate biomarkers for early signs of asthma.

AB - Preschool rhinovirus-induced wheeze is associated with an increased risk of asthma. In adult asthma, exhaled volatile organic compounds (VOC) are associated with inflammatory activity. We therefore hypothesised that acute preschool wheeze is accompanied by a differential profile of exhaled VOC, which is maintained after resolution of symptoms in those children with rhinovirus-induced wheeze.We included 178 children (mean +/- SD age 22 +/- 9 months) from the EUROPA cohort comparing asymptomatic and wheezing children during respiratory symptoms and after recovery. Naso- and oropharyngeal swabs were tested for rhinovirus by quantitative PCR. Breath was collected via a spacer and analysed using an electronic nose. Between-group discrimination was assessed by constructing a 1000-fold cross-validated receiver operating characteristic curve. Analyses were stratified by rhinovirus presence/absence.Wheezing children demonstrated a different VOC profile when compared with asymptomatic children (pExhaled molecular profiles differ between preschool children with and without acute respiratory wheeze. This appears to be sustained in children with rhinovirus-induced wheeze after resolution of symptoms. Therefore, exhaled VOC may qualify as candidate biomarkers for early signs of asthma.

KW - VOLATILE ORGANIC-COMPOUNDS

KW - 1ST 6 YEARS

KW - NITRIC-OXIDE

KW - PRESCHOOL WHEEZERS

KW - CHILDHOOD ASTHMA

KW - VIRAL-INFECTIONS

KW - ELECTRONIC NOSE

KW - FOLLOW-UP

KW - BREATH

KW - LIFE

U2 - 10.1183/09031936.00044414

DO - 10.1183/09031936.00044414

M3 - Article

SN - 0903-1936

VL - 45

SP - 440

EP - 448

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 2

ER -

Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze

Abstract

Keywords

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