Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell lass

JA Postigo, YD Van der Werf, J Korf, HJ Krugers*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    6 Citations (Scopus)

    Abstract

    The loss of dentate gyrus (DG) granular cells after removal of the rat adrenal glands (ADX) is mediated by a process that is apoptotic in nature. The present study was initiated to compare changes in the immunocytochemical distribution of the cell-cycle regulatory protein cyclin D1, which has been implicated in apoptosis, with the loss of DG granular cells after ADX. Our data indicate that cyclin D1-immunoreactivity (cyclin D1-ir) is enhanced in the rat dentate gyrus after adrenalectomy. The enhanced cyclin D1-ir shows a close relationship, both in time and space, with granular cell loss in the rat dentate gyrus that occurs after adrenalectomy. However, the enhanced cyclin D1-immunoreactivity was present in microglia and radial glia rather than in the dentate gyrus granular cells. This suggests that cyclin D1 is not directly involved in apoptosis of granular cells in the rat dentate gyrus after adrenalectomy. (C) 1998 Elsevier Science Ireland Ltd.

    Original languageEnglish
    Pages (from-to)107-110
    Number of pages4
    JournalNeuroscience Letters
    Volume241
    Issue number2-3
    Publication statusPublished - 30-Jan-1998

    Keywords

    • adrenalectomy
    • apoptosis
    • cell cycle
    • cyclin D1
    • dentate gyrus
    • microglia
    • radial glia
    • NERVOUS-SYSTEM
    • SILVER IMPREGNATION
    • NEURONAL APOPTOSIS
    • GENE-EXPRESSION
    • C-MYC
    • DEATH
    • DEGENERATION
    • IMMUNOREACTIVITY
    • IDENTIFICATION
    • INDUCTION

    Cite this