Altered frontal-amygdala effective connectivity during effortful emotion regulation in bipolar disorder

Liwen Zhang, Esther M. Opmeer*, Lisette van der Meer, Andre Aleman, Branislava Curcic-Blake, Henricus G. Ruhe

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

ObjectivesSufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation circuit. The aim of this study was to investigate whether BD patients show abnormal effective connectivity from the prefrontal areas to the amygdala during effortful ER (reappraisal).

MethodsForty participants (23 BD patients and 17 healthy controls [HC]) performed an ER task during functional magnetic resonance imaging. Using dynamic causal modeling, we investigated effective connectivity from the dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) to the amygdala, as well as connectivity between the DLPFC and VLPFC during reappraisal.

ResultsBoth BD patients and HC showed decreased negative affect ratings following reappraisal compared to attending negative pictures (P

ConclusionThe disturbance in BD patients in effective connectivity from the DLPFC to the amygdala while reappraising is indicative of insufficient prefrontal control. This impairment should be studied further in relation to cycling frequency and polarity of switches in BD patients.

Original languageEnglish
Pages (from-to)349-358
Number of pages10
JournalBipolar Disorders
Volume20
Issue number4
DOIs
Publication statusPublished - Jun-2018

Keywords

  • amygdala
  • bipolar disorder
  • dynamic causal modeling
  • effective connectivity
  • emotion regulation
  • prefrontal cortex
  • PREFRONTAL CORTEX
  • COGNITIVE CONTROL
  • NEGATIVE AFFECT
  • I DISORDER
  • BRAIN
  • FMRI
  • SCHIZOPHRENIA
  • CONSEQUENCES
  • NEUROBIOLOGY
  • METAANALYSIS

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