TY - JOUR
T1 - AML at older age
T2 - age-related gene expression profiles reveal a paradoxical down-regulation of p16(INK4A) mRNA with prognostic significance
AU - de Jonge, Hendrik J. M.
AU - de Bont, Eveline S. J. M.
AU - Valk, Peter J. M.
AU - Schuringa, Jan Jacob
AU - Kies, Marcel
AU - Woolthuis, Carolien M.
AU - Delwel, Ruud
AU - Veeger, Nic J. G. M.
AU - Vellenga, Edo
AU - Lowenberg, Bob
AU - Huls, Gerwin
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Acute myeloid leukemia (AML) has a different clinical and biologic behavior in patients at older age. To gain further insight into the molecular differences, we examined a cohort of 525 adults to compare gene expression profiles of the one-third of youngest cases (n = 175; median age 31 years) with the one-third of oldest cases (n = 175; median age 59 years). This analysis revealed that 477 probe sets were up-regulated and 492 probe sets were down-regulated with increasing age at the significance level of P
AB - Acute myeloid leukemia (AML) has a different clinical and biologic behavior in patients at older age. To gain further insight into the molecular differences, we examined a cohort of 525 adults to compare gene expression profiles of the one-third of youngest cases (n = 175; median age 31 years) with the one-third of oldest cases (n = 175; median age 59 years). This analysis revealed that 477 probe sets were up-regulated and 492 probe sets were down-regulated with increasing age at the significance level of P
KW - ACUTE-MYELOID-LEUKEMIA
KW - COLONY-STIMULATING FACTOR
KW - HEMATOPOIETIC STEM-CELLS
KW - TUMOR-SUPPRESSOR LOCUS
KW - MYELODYSPLASTIC SYNDROMES
KW - CELLULAR SENESCENCE
KW - ELDERLY-PATIENTS
KW - PATIENT AGE
KW - BMI-1
KW - PROTEINS
U2 - 10.1182/blood-2009-03-212688
DO - 10.1182/blood-2009-03-212688
M3 - Article
SN - 0006-4971
VL - 114
SP - 2869
EP - 2877
JO - Blood
JF - Blood
IS - 14
ER -