Abstract
Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.
| Original language | English |
|---|---|
| Pages (from-to) | 343-350 |
| Number of pages | 8 |
| Journal | Acs combinatorial science |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 8-May-2017 |
Keywords
- ammonia Ugi reaction
- European Lead Factory
- isocyanide
- multicomponent reaction
- tetrazolopiperidinone
- Ugi reaction
- amino acid
- ammonia
- cyanide
- ester
- piperidone derivative
- tetrazole derivative
- chemical structure
- chemistry
- human
- molecular library
- synthesis
Datasets
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CCDC 1485014: Experimental Crystal Structure Determination
Patil, P. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłuścik, J. (Contributor) & Dömling, A. (Contributor), University of Groningen, 13-Jun-2016
DOI: 10.5517/ccdc.csd.cc1lv8pd
Dataset
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CCDC 1485015: Experimental Crystal Structure Determination
Patil, P. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłuścik, J. (Contributor) & Dömling, A. (Contributor), University of Groningen, 13-Jun-2016
DOI: 10.5517/ccdc.csd.cc1lv8qf
Dataset
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CCDC 1485231: Experimental Crystal Structure Determination
Patil, P. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłuścik, J. (Contributor) & Dömling, A. (Contributor), University of Groningen, 13-Jun-2016
DOI: 10.5517/ccdc.csd.cc1lvhpm
Dataset