Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer

Rob Noorlag, Koos Boeve, Max J. H. Witjes, Ronald Koole, Ton L. M. Peeters, Ed Schuuring, Stefan M. Willems, Robert J. J. van Es*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

Background. Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited.

Methods. In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases.

Results. CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers.

Conclusion. Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. (C) 2016 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalHead and Neck: Journal of the Sciences and Specialties of the Head and Neck
Volume39
Issue number2
DOIs
Publication statusPublished - Feb-2017
EventSpring Congress of the Dutch-Society-of-Oral-and-Maxillofacial-Surgery (NVMKA) - Rotterdam, Netherlands
Duration: 29-May-2015 → …

Keywords

  • CCND1
  • cyclin D1
  • early oral cancer
  • occult nodal metastasis
  • biomarker
  • SQUAMOUS-CELL CARCINOMA
  • MESSENGER-RNA LEVELS
  • NECK DISSECTION
  • MULTICENTER TRIAL
  • COPY NUMBER
  • EXPRESSION
  • BIOPSY
  • HEAD
  • GENE
  • MANAGEMENT

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