An anti-aging vaccine: BCG turns back the clock on remyelination failure

Janssen M. Kotah; Bart J.L. Eggen

doi:10.1016/j.immuni.2024.08.001

An anti-aging vaccine: BCG turns back the clock on remyelination failure

Janssen M. Kotah
, Bart J.L. Eggen^*

^*Corresponding author for this work

Senescence, Stem Cells, and Inflammation (SSI)

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.

Original language	English
Pages (from-to)	2005-2007
Number of pages	3
Journal	Immunity
Volume	57
Issue number	9
DOIs	https://doi.org/10.1016/j.immuni.2024.08.001
Publication status	Published - 10-Sept-2024

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An anti-aging vaccineFinal publisher's version, 2.37 MBLicence: Taverne

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title = "An anti-aging vaccine: BCG turns back the clock on remyelination failure",

abstract = "Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.",

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AU - Eggen, Bart J.L.

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N2 - Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.

AB - Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.

UR - https://www.scopus.com/pages/publications/85204049103

U2 - 10.1016/j.immuni.2024.08.001

DO - 10.1016/j.immuni.2024.08.001

M3 - Comment/Letter to the editor

C2 - 39260352

AN - SCOPUS:85204049103

SN - 1074-7613

VL - 57

SP - 2005

EP - 2007

JO - Immunity

JF - Immunity

IS - 9

ER -

An anti-aging vaccine: BCG turns back the clock on remyelination failure

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