An artificial metalloenzyme for olefin metathesis

Clemens Mayer; Dennis G. Gillingham; Thomas R. Ward; Donald Hilvert

doi:10.1039/c1cc15005g

An artificial metalloenzyme for olefin metathesis

Clemens Mayer, Dennis G. Gillingham, Thomas R. Ward, Donald Hilvert^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

137 Citations (Scopus)

Abstract

A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.

Original language	English
Pages (from-to)	12068-12070
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	44
DOIs	https://doi.org/10.1039/c1cc15005g
Publication status	Published - 28-Nov-2011
Externally published	Yes

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title = "An artificial metalloenzyme for olefin metathesis",

abstract = "A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.",

author = "Clemens Mayer and Gillingham, {Dennis G.} and Ward, {Thomas R.} and Donald Hilvert",

year = "2011",

month = nov,

day = "28",

doi = "10.1039/c1cc15005g",

language = "English",

volume = "47",

pages = "12068--12070",

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issn = "1359-7345",

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T1 - An artificial metalloenzyme for olefin metathesis

AU - Mayer, Clemens

AU - Gillingham, Dennis G.

AU - Ward, Thomas R.

AU - Hilvert, Donald

PY - 2011/11/28

Y1 - 2011/11/28

N2 - A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.

AB - A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.

UR - http://www.scopus.com/inward/record.url?scp=80155131668&partnerID=8YFLogxK

U2 - 10.1039/c1cc15005g

DO - 10.1039/c1cc15005g

M3 - Article

C2 - 21991583

AN - SCOPUS:80155131668

SN - 1359-7345

VL - 47

SP - 12068

EP - 12070

JO - Chemical Communications

JF - Chemical Communications

IS - 44

ER -

An artificial metalloenzyme for olefin metathesis

Abstract

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