An artificial metalloenzyme for olefin metathesis

Clemens Mayer, Dennis G. Gillingham, Thomas R. Ward, Donald Hilvert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

126 Citations (Scopus)


A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.

Original languageEnglish
Pages (from-to)12068-12070
Number of pages3
JournalChemical Communications
Issue number44
Publication statusPublished - 28-Nov-2011
Externally publishedYes

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