An Economic Evaluation of Sacubitril/Valsartan for Heart Failure Patients in the Netherlands

Simon van der Pol*, Fabian Degener, Maarten J. Postma, Pepijn Vemer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

Background: In September 2014, the PARADIGM-HF trial showed the heart failure drug combination sacubitril/valsartan to be superior to enalapril for patients with a reduced ejection fraction. Objectives: To determine the incremental cost-effectiveness of sacubitril/valsartan compared with enalapril in the Netherlands using the clinical data from the PARADIGM-HF trial. Methods: To compare sacubitril/valsartan and enalapril in a cost-effectiveness study, a Markov model was developed using the effectiveness data from the PARADIGM-HF trial. A health care payer's perspective was applied in the economic evaluation. The developed model was used to evaluate the costeffectiveness for sacubitril/valsartan at different per diem prices. Results: The base-case analysis showed that sacubitril/valsartan can be cost-effective at maximum daily costs of (sic)5.50 and (sic)14.14 considering willingness-to-pay thresholds of (sic)20,000 and (sic)50,000 per quality-adjusted life-year (QALY), respectively. Sensitivity analysis demonstrated the robustness of the model, identifying only the price of sacubitril/valsartan and the mortality within the sacubitril/valsartan group as significant drivers of the cost-effectiveness ratio. Sacubitril/valsartan was cost-effective at a willingness-to-pay threshold of (sic)20,000 per QALY ((sic)50,000 per QALY) in more than 80% of the replications with certainty at the price point of(sic) ((sic)10). Conclusions: Sacubitril/valsartan can be considered a cost-effective treatment at a daily price of 5.25. Unless priced lower than enalapril (

Original languageEnglish
Pages (from-to)388-396
Number of pages9
JournalValue in Health
Volume20
Issue number3
DOIs
Publication statusPublished - Mar-2017

Keywords

  • economic evaluation
  • heart failure
  • valsartan/sacubitril
  • INTENSIVE-CARE UNITS
  • NEPRILYSIN INHIBITION
  • COST-EFFECTIVENESS
  • EJECTION FRACTION
  • ENALAPRIL
  • LCZ696
  • HOSPITALIZATION
  • POPULATION
  • PREVALENCE
  • IVABRADINE

Cite this