An Infant Formula with Large, Milk Phospholipid-Coated Lipid Droplets Supports Adequate Growth and Is Well-Tolerated in Healthy, Term Asian Infants: A Randomized, Controlled Double-Blind Clinical Trial

Oon Hoe Teoh, Tan Pih Lin, Marieke Abrahamse-Berkeveld*, Antoinette Winokan, Yap Seng Chong, Fabian Yap, Maya Marintcheva-Petrova, Eline M. van der Beek, Lynette P. Shek

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Lipids are essential for healthy infant growth and development. The structural complexity of lipids in human milk is not present in infant milk formula (IF). A concept IF was developed mimicking more closely the structure and composition of human milk fat globules. The current study evaluates whether a concept IF with large, milk phospholipid-coated lipid droplets (mode diameter 3 to 5 mu m) is equivalent to standard IF with regard to growth adequacy and safety in healthy, term Asian infants. In this randomized, double-blind, controlled trial, infants were randomized after parents decided to introduce formula. Infants received a standard IF with (Control) or without the specific prebiotic mixture scGOS/lcFOS (9:1 ratio; Control w/o prebiotics), or a Concept IF with large, milk phospholipid-coated lipid droplets and the prebiotic mixture. A group of 67 breastfed infants served as a reference. As a priori defined, only those infants who were fully intervention formula-fed

Original languageEnglish
Article number634
Number of pages16
JournalNutrients
Volume14
Issue number3
DOIs
Publication statusPublished - 1-Feb-2022

Keywords

  • lipid droplet structure
  • safety
  • growth adequacy
  • infant formula
  • FAT GLOBULE-MEMBRANE
  • GALACTO-OLIGOSACCHARIDES
  • FRUCTO-OLIGOSACCHARIDES
  • ABSORPTION
  • NUTRITION
  • EMULSIONS
  • DIGESTION
  • MIXTURE
  • SIZES
  • DIET

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