TY - JOUR
T1 - An instrument dedicated for modelling of pulmonary radiotherapy
AU - Niezink, Anne G. H.
AU - Dollekamp, Nienke J.
AU - Elzinga, Harriet J.
AU - Borger, Denise
AU - Boer, Eduard J. H.
AU - Ubbels, Jan F.
AU - Woltman- van Iersel, Marleen
AU - van der Leest, Annija H. D.
AU - Beijert, Max
AU - Groen, Harry J. M.
AU - Kraan, Jan
AU - Hiltermann, Thijo J. N.
AU - Wekken, van der, Anthonie J.
AU - van Putten, John W. G.
AU - Rutgers, Steven R.
AU - Pieterman, Remge M.
AU - de Hosson, Sander M.
AU - Roenhorst, Anke W. J.
AU - Langendijk, Johannes A.
AU - Widder, Joachim
PY - 2015/4
Y1 - 2015/4
N2 - Background and purpose: Radiotherapy plays a pivotal role in lung cancer treatment. Selection of patients for new (radio)therapeutic options aiming at improving outcomes requires reliable and validated prediction models. We present the implementation of a prospective platform for evaluation and development of lung radiotherapy (proPED-LUNG) as an instrument enabling multidimensional predictive modelling.Materials and methods: ProPED-LUNG was designed to comprise relevant baseline and follow up data of patients receiving pulmonary radiotherapy with curative intent. Patient characteristics, diagnostic and staging information, treatment parameters including full dose-volume-histograms, tumour control, survival, and toxicity are scored. Besides physician-rated data, a range of patient-rated data regarding symptoms and health-related quality-of-life are collected.Results: After 18 months of accrual, 315 patients have been included (accrual rate, 18 per month). Of the first hundred patients included, 70 received conformal (chemo)radiotherapy and 30 underwent stereotactic radiotherapy. Compliance at 3 and 6 months follow-up was 96-100% for patient-rated, and 8194% for physician-rated assessments. For data collection, 0.4 FTE were allocated in a 183 FTE department (0.2%).Conclusions: ProPED-LUNG is feasible with high compliance rates and yields a large amount of high quality prospective disease-related, treatment-related, patient- and physician-rated data which can be used to evaluate new developments in pulmonary radiotherapy. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
AB - Background and purpose: Radiotherapy plays a pivotal role in lung cancer treatment. Selection of patients for new (radio)therapeutic options aiming at improving outcomes requires reliable and validated prediction models. We present the implementation of a prospective platform for evaluation and development of lung radiotherapy (proPED-LUNG) as an instrument enabling multidimensional predictive modelling.Materials and methods: ProPED-LUNG was designed to comprise relevant baseline and follow up data of patients receiving pulmonary radiotherapy with curative intent. Patient characteristics, diagnostic and staging information, treatment parameters including full dose-volume-histograms, tumour control, survival, and toxicity are scored. Besides physician-rated data, a range of patient-rated data regarding symptoms and health-related quality-of-life are collected.Results: After 18 months of accrual, 315 patients have been included (accrual rate, 18 per month). Of the first hundred patients included, 70 received conformal (chemo)radiotherapy and 30 underwent stereotactic radiotherapy. Compliance at 3 and 6 months follow-up was 96-100% for patient-rated, and 8194% for physician-rated assessments. For data collection, 0.4 FTE were allocated in a 183 FTE department (0.2%).Conclusions: ProPED-LUNG is feasible with high compliance rates and yields a large amount of high quality prospective disease-related, treatment-related, patient- and physician-rated data which can be used to evaluate new developments in pulmonary radiotherapy. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
KW - Lung cancer
KW - Thoracic radiotherapy
KW - Patient-rated outcome measures
KW - CELL LUNG-CANCER
KW - PROPHYLACTIC CRANIAL IRRADIATION
KW - THORACIC RADIOTHERAPY
KW - COMPLETE REMISSION
KW - SELECTION
U2 - 10.1016/j.radonc.2015.03.020
DO - 10.1016/j.radonc.2015.03.020
M3 - Article
SN - 0167-8140
VL - 115
SP - 3
EP - 8
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 1
ER -